Pharmacological and Lifestyle Factors Modulating Serum Paraoxonase-1 Activity

被引：29
作者：
Camps, Jordi [1 ]
Marsillach, Judit [1 ]
Joven, Jorge [1 ]
机构：
[1] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Ctr Recerca Biomed, Reus 43201, Catalunya, Spain
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 08期
关键词：
Apolipoprotein A-I; fibrates; high-density lipoproteins; lipid peroxidation; nutrition; paraoxonase-1; rosiglitazone; statins; HIGH-DENSITY-LIPOPROTEIN; REDUCES OXIDATIVE STRESS; POMEGRANATE JUICE CONSUMPTION; HORMONE-REPLACEMENT THERAPY; CHOLESTERYL ESTER TRANSFER; E-DEFICIENT MICE; CARDIOVASCULAR-DISEASE; A-I; POSTPRANDIAL PARAOXONASE-1; PESTICIDE SENSITIVITY;
D O I：
10.2174/138955709788681591
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Paraoxonase-1 is a lactonase and an esterase and it plays a protective role in toxicity as well as in diseases involving oxidative stress. Recently, insights into how it may be modulated by environmental factors have acquired clinical relevance. This article reviews the state-of-the-art evidence regarding PON1 modulation by pharmacological products as well as nutritional and lifestyle factors.
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收藏
页码：911 / 920
页数：10
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