Caloric Restriction in Older Adults-Differential Effects of Weight Loss and Reduced Weight on Brain Structure and Function

被引：85

作者：

Prehn, Kristin ^{[1
,2
]}

von Schwartzenberg, Reiner Jumpertz ^{[3
,4
]}

Mai, Knut ^{[3
,4
]}

Zeitz, Ulrike ^{[3
,4
]}

Witte, A. Veronica ^{[1
,2
,7
]}

Hampel, Dierk ^{[3
,4
]}

Szela, Anna-Maria ^{[1
,2
]}

Fabian, Sonja ^{[1
,2
]}

Grittner, Ulrike ^{[5
,6
]}

Spranger, Joachim ^{[3
,4
]}

Floeel, Agnes ^{[1
,2
]}

机构：

[1] Charit Univ Med Berlin, Dept Neurol, Charitpl 1, D-10117 Berlin, Germany

[2] Charit Univ Med Berlin, NeuroCure Clin Res Ctr, Charitpl 1, D-10117 Berlin, Germany

[3] Charit Univ Med Berlin, Expt & Clin Res Ctr, Dept Endocrinol Diabet & Nutr, Berlin, Germany

[4] Charit Univ Med Berlin, Ctr Cardiovasc Res, Berlin, Germany

[5] Charit Univ Med Berlin, Dept Biostat & Clin Epidemiol, Berlin, Germany

[6] Charit Univ Med Berlin, Ctr Stroke Res, Berlin, Germany

[7] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Aging & Obes Grp, Leipzig, Germany

来源：

CEREBRAL CORTEX | 2017年 / 27卷 / 03期

关键词：

aging; hippocampus; nutritional intervention; resting-state fMRI; VBM; MILD COGNITIVE IMPAIRMENT; LATE-LIFE OBESITY; DIETARY RESTRICTION; BEHAVIORAL DEFICITS; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; GLUCOSE-LEVELS; ENERGY-INTAKE; NETWORKS; CONNECTIVITY;

D O I：

10.1093/cercor/bhw008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dietary modifications such as caloric restriction (CR) have been suggested as a means to improve memory and prevent agerelated decline. However, it is unclear whether those effects remain stable over time or are related specifically to negative energy balance during the weight loss phase of CR. Using a randomized interventional design, we investigated changes in recognition memory and neural correlates in postmenopausal obese women (n = 19): 1) after intense weight loss in the course of a 12-week low-caloric diet (reduced body weight and negative energy balance) and 2) after having sustained the reduced weight over 4 more weeks (reduced body weight, but energy balance equilibrium). Participants were contrasted to a control group (n = 18) instructed not to change dietary habits. In the CR group, we found improved recognition memory, paralleled by increased gray matter volume in inferior frontal gyrus and hippocampus, and augmented hippocampal resting-state functional connectivity to parietal areas. Moreover, effects were specific for transient negative energy balance and could not be detected after subsequent weight maintenance. Our data demonstrate for the first time in humans that beneficial effects of CR on brain structure and function are due to weight loss rather than an overall reduced weight.

引用

页码：1765 / 1778

页数：14

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