Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine

被引：16

作者：

Beng, Timothy K. ^{[1
]}

Yousaf, Taher I. ^{[1
]}

Coldham, Iain ^{[2
]}

Gawley, Robert E. ^{[1
]}

机构：

[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

[2] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 20期

基金：

美国国家科学基金会;

关键词：

HIGHLY ENANTIOSELECTIVE REACTIONS; ALPHA-SULFONYL CARBANIONS; THERMODYNAMIC RESOLUTION; KINETIC RESOLUTION; NMR-SPECTROSCOPY; 2-LITHIOPYRROLIDINES; N-BOC-2-LITHIOPYRROLIDINE; EQUILIBRATION; BARRIER;

D O I：

10.1021/ja900755a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The barriers to enantiomerization of N-trimethylallyl-2-lithiopyrrolidine have been measured in the presence of sparteine, 1, N,N'-diisopropylbispidine, 2, and diaminoalkoxide 3. We have additionally demonstrated a rare example of a catalytic dynamic resolution using either of two ligands, achieving enantiomer ratios of up to 93:7.

引用

页码：6908 / +

页数：3

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