Relationship between serum levels of C-reactive protein and α1-antitrypsin and insulin resistance in obese women.

Adipose tissue produces cytokines involved in insulin resistance (IR) such as IL-6, IL-8, TNF-a and proinflammatory molecules such as C reactive protein (CRP). alpha l-antitrypsin is an inflammation-sensitive plasma protein. The objective of this study is to determine the correlation between serum CRP high-sensitivity (CRPhs) and al-antitrypsin levels with IR indices in obese Venezuelan women. The study population consisted of 15 normal weight women (BMI 21.8 +/- 1.9 kg/m(2)) and 15 obese women (BMI 35.3 +/- 5.3 kg/m(2)). Obese and lean women underwent a 2 h-75g oral glucose tolerance test and the following indices were calculated: homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of cell function (HOMA-beta), Matsuda Index and Insulinogenic Index. The relationship between serum CRPhs and alpha 1-antitrypsin levels and these indices were determined. Obese women had higher CRPhs levels (p = 0.001) compared with normal weight women. In obese women, serum CRPhs levels were positively correlated with HOMA-IR (r=0.73, p=0.0021), HOMA-beta (r=0.53, p=0.031) and negatively correlated with the Matsuda Index (r= -0.60, p=0.017). No correlation between serum levels of a 1-antitrypsin and IR indices in the obese group and the lean group was observed. There was a relation between serum CRPhs levels and insulin resistance, suggesting a role of subclinical inflammation in IR.