PF1163A and B, new antifungal antibiotics produced by Penicillium sp I.: Taxonomy of producing strain, fermentation, isolation and biological activities

被引：16

作者：

Nose, H ^{[1
]}

Seki, A ^{[1
]}

Yaguchi, T ^{[1
]}

Hosoya, A ^{[1
]}

Sasaki, T ^{[1
]}

Hoshiko, S ^{[1
]}

Shomura, T ^{[1
]}

机构：

[1] Meiji Seika Kaisha Ltd, Pharmaceut Res Ctr, Kohoku Ku, Yokohama, Kanagawa 2220002, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 01期

关键词：

D O I：

10.7164/antibiotics.53.33

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies. PF1163A and B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. These compounds inhibited the er,ergosterol biosynthesis in Candida albicans.

引用

页码：33 / 37

页数：5

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