Type-specific prevalence and persistence of human papillomavirus in women in the United States who are referred for typing as a component of cervical cancer screening

被引:34
作者
Howe, Elizabeth Ralston [2 ]
Li, Zhongze [1 ]
McGlennen, Ronald C. [3 ]
Hellerstedt, Wendy L. [2 ]
Downs, Levi S., Jr. [1 ,4 ]
机构
[1] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Maternal & Child Hlth Program, Minneapolis, MN USA
[3] Access Genet, Minneapolis, MN USA
[4] Univ Minnesota, Sch Med, Dept Obstet Gynecol & Womens Hlth, Minneapolis, MN 55455 USA
关键词
cervical cancer screening; HPV prevalence; PCR HPV test; type-specific HPV persistence; POLYMERASE-CHAIN-REACTION; NATURAL-HISTORY; YOUNG-WOMEN; HPV; INFECTION; AMPLIFICATION; DNA; LESIONS; ASSAY;
D O I
10.1016/j.ajog.2008.10.050
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The purpose of this study was to report type-specific prevalence and persistence of human papillomavirus (HPV) in women who underwent cytologic screening. STUDY DESIGN: We examined HPV prevalence in 73,371 women who had type-specific HPV testing in 1 of 23 clinical laboratories in the United States. Persistence was evaluated in 963 women who were tested within 8-16 months of their index test. RESULTS: HPV was detected in 31% of the women, and high-risk HPV was detected in 23% of the women. HPV-16, -53, -52, and -31 were the most prevalent types. Of the 953 women with 2 tests, 39% of the women had persistent HPV infection. High-risk HPV persistence was detected in 34% of the women who were positive initially for high-risk HPV. CONCLUSION: Approximately one-third of our sample had HPV; of those women who were retested within 8-16 months, more than one-third had persistent infection. Among women with high-risk HPV infections, the likelihood of persistence was highest with HPV genotypes that were phylogenetically similar to HPV-16.
引用
收藏
页码:245.e1 / 245.e7
页数:7
相关论文
共 25 条
[1]   Human papillomavirus in cervical screening and vaccination [J].
Crosbie, Emma J. ;
Kitchener, Henry C. .
CLINICAL SCIENCE, 2006, 110 (05) :543-552
[2]   Prevalence of HPV infection among females in the United States [J].
Dunne, Eileen F. ;
Unger, Elizabeth R. ;
Sternberg, Maya ;
McQuillan, Geraldine ;
Swan, David C. ;
Patel, Sonya S. ;
Markowitz, Lauri E. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (08) :813-819
[3]   Epidemiologic evidence and human papillomavirus infection as a necessary cause of cervical cancer [J].
Franco, EL ;
Rohan, TE ;
Villa, LL .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (06) :506-511
[4]  
Gerberding J.L., 2004, Report to Congress: Prevention o fgenital human papillomavirus infection centersfor disease control andprevention
[5]   Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The young women's health study [J].
Giuliano, AR ;
Harris, R ;
Sedjo, RL ;
Baldwin, S ;
Roe, D ;
Papenfuss, MR ;
Abrahamsen, M ;
Inserra, P ;
Olvera, S ;
Hatch, K .
JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (04) :462-469
[6]  
Gravitt PE, 2000, J CLIN MICROBIOL, V38, P357
[7]   Natural history of cervicovaginal papillomavirus infection in young women [J].
Ho, GYF ;
Bierman, R ;
Beardsley, L ;
Chang, CJ ;
Burk, RD .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (07) :423-428
[9]   Type-specific persistence of high-risk human papillomavirus infections in the new independent states of the former soviet union cohort study [J].
Kulmala, Satu-Maria A. ;
Shabalova, Irena P. ;
Petrovitchev, Nikolay ;
Syrjanen, Kari J. ;
Gyllensten, Ulf B. ;
Johansson, Bo C. ;
Syrjanen, Stina M. .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (01) :17-22
[10]   Human papillomavirus testing with the hybrid capture 2 assay and PCR as screening tools [J].
Kulmala, SM ;
Syrjänen, S ;
Shabalova, I ;
Petrovichev, N ;
Kozachenko, V ;
Podistov, J ;
Ivanchenko, O ;
Zakharenko, S ;
Nerovjna, R ;
Kljukina, L ;
Branovskaja, M ;
Grunberga, V ;
Juschenko, A ;
Tosi, P ;
Santopietro, R ;
Syrjänen, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (06) :2470-2475