A malleable catalyst dominates the metabolism of drugs

被引:51
作者
Guengerich, F. Peter
机构
[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Nashville, TN 37232 USA
关键词
D O I
10.1073/pnas.0606333103
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:13565 / 13566
页数:2
相关论文
共 20 条
[1]   Pyrene-pyrene complexes at the active site of cytochrome P450 3A4: Evidence for a multiple substrate binding site [J].
Dabrowski, MJ ;
Schrag, ML ;
Wienkers, LC ;
Atkins, WM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (40) :11866-11867
[2]   Structural basis for ligand promiscuity in cytochrome P450 3A4 [J].
Ekroos, Marika ;
Sjogren, Tove .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (37) :13682-13687
[3]   Resolution of multiple substrate binding sites in cytochrome P450 3A4: The stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration [J].
Fernando, H ;
Halpert, JR ;
Davydov, DR .
BIOCHEMISTRY, 2006, 45 (13) :4199-4209
[4]  
Guengerich F., 2005, CYTOCHROME P450 STRU, P377, DOI DOI 10.1007/0-387-27447-2_10
[5]  
GUENGERICH FP, 1986, J BIOL CHEM, V261, P5051
[6]   Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4 [J].
Isin, EM ;
Guengerich, FP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (14) :9127-9136
[7]   COMPARISON OF EXPERIMENTAL BINDING DATA AND THEORETICAL MODELS IN PROTEINS CONTAINING SUBUNITS [J].
KOSHLAND, DE ;
NEMETHY, G ;
FILMER, D .
BIOCHEMISTRY, 1966, 5 (01) :365-+
[8]   Cytochrome P450 3A4-catalyzed testosterone 6β-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps [J].
Krauser, JA ;
Guengerich, FP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) :19496-19506
[9]   The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions [J].
Lehmann, JM ;
McKee, DD ;
Watson, MA ;
Willson, TM ;
Moore, JT ;
Kliewer, SA .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (05) :1016-1023
[10]   Substrate-induced conformational, changes in the transmembrane segments of human P-glycoprotein - Direct evidence for the substrate-induced fit mechanism for drug binding [J].
Loo, TW ;
Bartlett, MC ;
Clarke, DM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (16) :13603-13606