Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice

被引：28

作者：

Donado-Pestana, Carlos M. ^{[1
]}

Pessoa, Erika V. M. ^{[1
]}

Rodrigues, Larissa ^{[1
]}

Rossi, Rafaela ^{[1
]}

Moura, Marcio H. C. ^{[1
]}

dos Santos-Donado, Priscila R. ^{[2
]}

Castro, Erique ^{[3
]}

Festuccia, William T. ^{[3
]}

Genovese, Maria Ines ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Alimentos & Nutr Expt, Av Prof Lineu Prestes 580,Bloco 14, Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz ESALQ, Dept Agroind Alimentos & Nutr, Piracicaba, SP, Brazil

[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Sao Paulo, SP, Brazil

来源：

FOOD CHEMISTRY | 2021年 / 340卷

基金：

巴西圣保罗研究基金会;

关键词：

Phenolic compounds; Cambucizeiro; Myrtaceae; Obesity; Inflammation; EUGENIA-DYSENTERICA DC; HIGH-FAT; METABOLIC-DISORDERS; PHENOLIC-COMPOUNDS; GLUCOSE-UPTAKE; MTORC2; INFLAMMATION; RICTOR; CARDIOPROTECTION; LIPOGENESIS;

D O I：

10.1016/j.foodchem.2020.128169

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polyphenols from cambuci (CBC) (Campomanesia phaea (O. Berg.)), a Brazilian native fruit, were investigated on therapeutic actions mitigating insulin resistance and hepatic steatosis in high-fat-sucrose diet (HFS) induced obese mice. For this, C57BL/6J mice fed with a obesogenic and diabetogenic HFS diet were administered with either water or two CBC doses (36 or 74 mg gallic acid equivalent (GAE)/kg body weight) by gavage from week 6 to week 14 (end-point) of HFS feeding. CBC reduced body weight gain, inflammation, hepatic steatosis, hyperglycemia, glucose intolerance, and insulin resistance in liver and skeletal muscle of obese mice, and such effects were associated with activation of Akt and AMPK in these tissues. In conclusion, polyphenols from CBC show important therapeutic actions ameliorating obesity-associated complications.

引用

页数：9

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