Greater development of 1,2-dimethylhydrazine-induced colon cancer in a rat model of type 2 diabetes mellitus

被引：9
作者：
Terai, K. [1 ]
Sakamoto, K. [1 ]
Goto, M. [1 ]
Matsuda, M. [1 ]
Kasamaki, S. [1 ]
Shinmura, K. [1 ]
Takita, N. [1 ]
Kamano, T. [1 ]
机构：
[1] Juntendo Univ, Sch Med, Dept Coloproctol Surg, Bunkyo Ku, Tokyo 1138421, Japan
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2006年 / 34卷 / 04期
关键词：
1,2-dimethylhydrazine; carcinogens; colon cancer; type 2 diabetes mellitus; rat model;
D O I：
10.1177/147323000603400407
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Several clinical cohort and case-control studies have suggested a link between diabetes and colon cancer. Otsuka Long-Evans Tokushima Fat (OLETF) rats spontaneously develop type 2 diabetes mellitus and Long-Evans Tokushima Otsuka (LETO) rats are non-diabetic. The relationship between type 2 diabetes mellitus and colon cancer was examined in these rats. The carcinogen 1,2-dimethylhydrazine was administered subcutaneously once weekly for 10 weeks, and the animals were killed and necropsied in week 29. All OLETY rats and 80% of the LETO rats developed cancer. The number of colon cancers per rat was significantly greater in the diabetic than in the non-diabetic rats. Although the tumours tended to be larger in diabetic rats, the difference was not statistically significant. No significant differences were observed in the depth of invasion or histological type of cancer in the two groups. Type 2 diabetes mellitus may enhance the generation and growth of colon cancer.
引用
收藏
页码：385 / 389
页数：5
相关论文
共 15 条
  • [1] Insulin injections promote the growth of aberrant crypt foci in the colon of rats
    Corpet, DE
    Jacquinet, C
    Peiffer, G
    Tache, S
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 27 (03): : 316 - 320
  • [2] INSULIN AND COLON-CANCER
    GIOVANNUCCI, E
    [J]. CANCER CAUSES & CONTROL, 1995, 6 (02) : 164 - 179
  • [3] Insulin, insulin-like growth factors and colon cancer: A review of the evidence
    Giovannucci, E
    [J]. JOURNAL OF NUTRITION, 2001, 131 (11) : 3109S - 3120S
  • [4] Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women
    Hu, FB
    Manson, JE
    Liu, SM
    Hunter, D
    Colditz, GA
    Michels, KB
    Speizer, FE
    Giovannucci, E
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (06): : 542 - 547
  • [5] Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women
    Kaaks, R
    Toniolo, P
    Akhmedkhanov, A
    Lukanova, A
    Biessy, C
    Dechaud, H
    Rinaldi, S
    Zeleniuch-Jacquotte, A
    Shore, RE
    Riboli, E
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (19): : 1592 - 1600
  • [6] SPONTANEOUS LONG-TERM HYPERGLYCEMIC RAT WITH DIABETIC COMPLICATIONS - OTSUKA LONG-EVANS TOKUSHIMA FATTY (OLETF) STRAIN
    KAWANO, K
    HIRASHIMA, T
    MORI, S
    SAITOH, Y
    KUROSUMI, M
    NATORI, T
    [J]. DIABETES, 1992, 41 (11) : 1422 - 1428
  • [7] Glucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan)
    Kono, S
    Honjo, S
    Todoroki, I
    Nishiwaki, M
    Hamada, H
    Nishikawa, H
    Koga, H
    Ogawa, S
    Nakagawa, K
    [J]. CANCER CAUSES & CONTROL, 1998, 9 (04) : 441 - 446
  • [8] Limburg PJ, 2005, CANCER EPIDEM BIOMAR, V14, P133
  • [9] Sandhu MS, 2002, J NATL CANCER I, V94, P972
  • [10] Abnormal glucose tolerance and the risk of cancer death in the United States
    Saydah, SH
    Loria, CM
    Eberhardt, MS
    Brancati, FL
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 157 (12) : 1092 - 1100
12