Effects of Extracellular Vesicles Derived from Mesenchymal Stem/Stromal Cells on Liver Diseases

被引：13
作者：
Zheng, Wenjie [1 ,2 ]
Yang, Yumin [3 ]
Sequeira, Russel Clive [2 ]
Bishop, Colin E. [2 ]
Atala, Anthony [2 ]
Gu, Zhifeng [1 ]
Zhao, Weixin [2 ]
机构：
[1] Nantong Univ, Affiliated Hosp, Res Ctr Clin Med, Nantong 226001, Jiangsu, Peoples R China
[2] Wake Forest Univ Hlth Sci, Wake Forest Inst Regenerat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA
[3] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2019年 / 14卷 / 05期
关键词：
Mesenchymal stem/stromal cells; extracellular vesicles; liver diseases; fibrosis; hepatocellular carcinoma; regenerative medicine; NATURAL-KILLER-CELLS; UMBILICAL-CORD BLOOD; STEM-CELLS; BONE-MARROW; STROMAL CELLS; HEPATOCELLULAR-CARCINOMA; INTERNATIONAL-SOCIETY; ALCOHOLIC CIRRHOSIS; SIGNALING PATHWAY; IN-VITRO;
D O I：
10.2174/1574888X14666190308123714
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Therapeutic effects of Mesenchymal Stem/Stromal Cells (MSCs) transplantation have been observed in various disease models. However, it is thought that MSCs-mediated effects largely depend on the paracrine manner of secreting cytokines, growth factors, and Extracellular Vesicles (EVs). Similarly, MSCs-derived EVs also showed therapeutic benefits in various liver diseases through alleviating fibrosis, improving regeneration of hepatocytes, and regulating immune activity. This review provides an overview of the MSCs, their EVs, and their therapeutic potential in treating various liver diseases including liver fibrosis, acute and chronic liver injury, and Hepatocellular Carcinoma (HCC). More specifically, the mechanisms by which MSC-EVs induce therapeutic benefits in liver diseases will be covered. In addition, comparisons between MSCs and their EVs were also evaluated as regenerative medicine against liver diseases. While the mechanisms of action and clinical efficacy must continue to be evaluated and verified, MSCs-derived EVs currently show tremendous potential and promise as a regenerative medicine treatment for liver disease in the future.
引用
收藏
页码：442 / 452
页数：11
相关论文
共 126 条
  • [1] Isolation and characterization of platelet-derived extracellular vesicles
    Aatonen, Maria T.
    Ohman, Tiina
    Nyman, Tuula A.
    Laitinen, Saara
    Gronholm, Mikaela
    Siljander, Pia R. -M.
    [J]. JOURNAL OF EXTRACELLULAR VESICLES, 2014, 3 (01)
  • [2] Effect of bone marrow-derived mesenchymal stromal cells on hepatoma
    Abd-Allah, Somia H.
    Shalaby, Sally M.
    El-Shal, Amal S.
    Abd Elkader, Eman
    Hussein, Samia
    Emam, Emad
    Mazen, Nehad F.
    El Kateb, Mohammed
    Atfy, Mha
    [J]. CYTOTHERAPY, 2014, 16 (09) : 1197 - 1206
  • [3] The potential of cell sheet technique on the development of hepatocellular carcinoma in rat models
    Alshareeda, Alaa T.
    Sakaguchi, Katsuhisa
    Abumaree, Mohammed
    Zin, Nur Khatijah Mohd
    Shimizu, Tatsuya
    [J]. PLOS ONE, 2017, 12 (08):
  • [4] Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development
    Ancans, Jains
    [J]. FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [5] Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling
    Aziz, Mohamed T. Abdel
    El Asmar, Mohamed F.
    Atta, Hazem M.
    Mahfouz, Soheir
    Fouad, Hanan H.
    Roshdy, Nagwa K.
    Rashed, Laila A.
    Sabry, Dina
    Hassouna, Amira A.
    Taha, Fatma M.
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2011, 30
  • [6] Effect of Mesenchymal Stem Cells and a Novel Curcumin Derivative on Notch1 Signaling in Hepatoma Cell Line
    Aziz, Mohamed Talaat Abdel
    Khaled, Hussien Mostafa
    El Hindawi, Ali
    Roshdy, Nagwa Kamal
    Rashed, Laila A.
    Sabry, Dina
    Hassouna, Amira A.
    Taha, Fatma
    Ali, Andwalaa Ibrahim
    [J]. BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [7] Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow
    Bliss, Sarah A.
    Sinha, Garima
    Sandiford, Oleta A.
    Williams, Lisa M.
    Engelberth, Daniel J.
    Guiro, Khadidiatou
    Isenalumhe, Leidy L.
    Greco, Steven J.
    Ayer, Seda
    Bryan, Margarette
    Kumar, Rakesh
    Ponzio, Nicholas M.
    Rameshwar, Pranela
    [J]. CANCER RESEARCH, 2016, 76 (19) : 5832 - 5844
  • [8] Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)
    Bourin, Philippe
    Bunnell, Bruce A.
    Casteilla, Louis
    Dominici, Massimo
    Katz, Adam J.
    March, Keith L.
    Redl, Heinz
    Rubin, J. Peter
    Yoshimura, Kotaro
    Gimble, Jeffrey M.
    [J]. CYTOTHERAPY, 2013, 15 (06) : 641 - 648
  • [9] Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury
    Bruno, Stefania
    Grange, Cristina
    Deregibus, Maria Chiara
    Calogero, Raffaele A.
    Saviozzi, Silvia
    Collino, Federica
    Morando, Laura
    Busca, Alessandro
    Falda, Michele
    Bussolati, Benedetta
    Tetta, Ciro
    Camussi, Giovanni
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (05): : 1053 - 1067
  • [10] Chen L, 2017, AM J TRANSL RES, V9, P1500
12345678910