The mammalian brain rsec6/8 complex

被引：238

作者：

Hsu, SC ^{[1
]}

Ting, AE ^{[1
]}

Hazuka, CD ^{[1
]}

Davanger, S ^{[1
]}

Kenny, JW ^{[1
]}

Kee, Y ^{[1
]}

Scheller, RH ^{[1
]}

机构：

[1] HEWLETT PACKARD CORP,PALO ALTO,CA 94034

来源：

NEURON | 1996年 / 17卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0896-6273(00)80251-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which Ts essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with a combined molecular weight of 743 kDa. The complex is broadly expressed in brain and displays a plasma membrane localization in nerve terminals. Membrane associated rsec6/8 complex coimmunoprecipitates with syntaxin, a plasma membrane protein critical for neurotransmission. These data suggest a role for the mammalian rsec6/8 complex in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus.

引用

收藏

页码：1209 / 1219

页数：11

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