Synthetic approaches to rapamycin .3. Synthesis of a C1-C21 fragment

被引：0

作者：

Harris, L

Jarowicki, K

Kocienski, P

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND

[2] GLAXO WELLCOME RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

SYNLETT | 1996年 / 09期

关键词：

rapamycin; asymmetric allylation; asymmetric hydrogenation; Heck reaction; immunosuppressant; ketenedithioacetal; alpha-oxoketene;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Key steps in two alternative approaches to the C10-C21 fragments 4 and 17 of the immunosuppressant rapamycin employ catalytic asymmetric allylation and catalytic asymmetric hydrogenation to introduce the first stereogenic centre at C14. Appendage of C1-C9 via trapping of an a-oxoketene intermediate generates the C1-C21 fragment 5.

引用

页码：903 / &

页数：4

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