A new neuroprotective pinusolide derivative from the leaves from Biota orientalis

被引：34

作者：

Koo, KA ^{[1
]}

Sung, SH ^{[1
]}

Kim, YC ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 06期

关键词：

Biota orientalis; 15-methoxypinusolidic acid; neuroprotective activity; ent-isopirnara-15-en-3; alpha; 8; alpha-diol; glutamate; Cupressaceae;

D O I：

10.1248/cpb.50.834

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new pinusolide derivative, 15-methoxypinusolidic acid (1), and another new isopimarane diterpene, entisopimara-15-en-3alpha,8alpha-diol (2) with three known diterpenes, lambertianic acid (3), isopimara-8(9),15-dien-18-oic acid (4) and isopimara-7(8),15-dien-3beta,18-diol (5) were isolated from the 90% MeOH fraction of Biota orientalis (L.) ENDL. (Cupressaceae) leaves. Chemical structures of 1-5 were elucidated by analyses of their spectral data, including the two-dimensional (2D) NMR technique. Compound 1 showed significant protective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.

引用

页码：834 / 836

页数：3

共 27 条

[1] N-METHYL-D-ASPARTATE ANTAGONISTS - READY FOR CLINICAL-TRIAL IN BRAIN ISCHEMIA [J].