Self-management of immunomodulatory drug treatment in multiple myeloma patients

被引:0
作者
Cransac, Amelie [1 ,2 ]
Aho, Serge [3 ,4 ]
Cosme, Edouard [1 ]
Chretien, Marie-Lorraine [5 ,6 ]
Favennec, Camille [5 ]
Schreder, Laure [7 ]
Boutet, Meredith [1 ]
Gueneau, Pauline [1 ]
Giroud, Maurice [2 ,8 ]
Caillot, Denis [5 ]
Boulin, Mathieu [1 ,9 ]
机构
[1] Dijon Univ Hosp, Dept Pharm, 14 Rue Paul Gaffarel, F-21000 Dijon, France
[2] Univ Burgundy & Franche Comte, LNC UMR1231, Dijon, France
[3] Dijon Univ Hosp, Hosp Epidemiol, Dijon, France
[4] Dijon Univ Hosp, Infect Control Dept, Dijon, France
[5] Dijon Univ Hosp, Dept Clin Hematol, Dijon, France
[6] Univ Burgundy & Franche Comte, SAPHIIR UMR 1231, Dijon, France
[7] Dijon Univ Hosp, Oncol Coordinat Ctr, Dijon, France
[8] Dijon Univ Hosp, Dept Neurol, Dijon, France
[9] Univ Burgundy & Franche Comte, EPICAD LNC UMR1231, Dijon, France
关键词
adherence; immunomodulatory drugs; multiple myeloma; questionnaire; self‐ management; side effects; PHARMACEUTICAL CARE; LENALIDOMIDE; SURVIVAL; OUTCOMES;
D O I
10.1111/ecc.13356
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective Immunomodulatory drugs (IMIDs: thalidomide, lenalidomide and pomalidomide) are widely used in patients with multiple myeloma (MM). The aim of our study was to validate a questionnaire to evaluate the self-capacity of MM patients to manage IMID treatment including side effects. Methods We used a method adapted from the recommendations of the European Organisation for Research and Treatment of Cancer (EORTC) to validate a French questionnaire for patients with MM treated with IMIDs. Results The face validity was evaluated in 15 patients and the construct validity in 56 patients. For discriminant validity, two groups were constituted by gender and depending on whether they had a previous IMID treatment. The median questionnaire score was 11.33/16 (IQR 9.75-12.08) with a minimum of 5.2 and a maximum of 14.75. For discriminant validity, a statistically significant difference was observed for patient capacity to contact healthcare professionals in specific situations and drug intake in case of swallowing disorder. Convergent validity showed an acceptable reliability for the scores of the different questions. Conclusion The questionnaire has shown to be a valid tool for the assessment of the adherence and side-effect management skills for MM patients with IMID treatment.
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页数:9
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