Multifunctional Core-Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo

被引：21
作者：
Chen, Yin-Yin [1 ,2 ]
Ma, Ping-An [1 ]
Yang, Dong-Mei [1 ,2 ]
Wu, Yuan [1 ,2 ]
Dai, Yun-Lu [1 ,2 ]
Li, Chun-Xia [1 ]
Lin, Jun [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 02期
基金：
中国国家自然科学基金;
关键词：
imaging agents; luminescence; magnetic properties; medicinal chemistry; nanostructures; UP-CONVERSION LUMINESCENCE; MESOPOROUS SILICA NANOPARTICLES; OPTICAL SPECTROSCOPY; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; UNIFORM; NANOCRYSTALS; DOXORUBICIN; SPHERES;
D O I：
10.1002/asia.201301262
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Multifunctional, mesoporous, silica-coated upconversion luminescent/magnetic NaGdF4:Yb/Er@NaGdF4:Yb@mSiO(2)PEG (referred to as UCNPS; PEG=polyethylene glycol) nanocomposites were fabricated through a phase-transfer-assisted surfactant-templating coating process, followed by hydrophilic polymer (PEG) functionalization to improve the stability and biocompatibility. The UCNP core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (MR) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. Proof-of-principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/MR dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers.
引用
收藏
页码：506 / 513
页数：8
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