Modifying tumor-associated macrophages An important adjunct to immunotherapy

被引：14

作者：

Fridlender, Zvi G. ^{[1
,2
]}

Albelda, Steven M. ^{[2
]}

机构：

[1] Hadassah Hebrew Univ, Med Ctr, Inst Pulm Med, Jerusalem, Israel

[2] Univ Penn, Thorac Oncol Res Lab, Philadelphia, PA 19104 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期

关键词：

tumor associated macrophages; immunotherapy; lung cancer; DMXAA; vaccines; AGENT 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID; LUNG-CANCER; ACTIVATION; SIGNALS; DMXAA;

D O I：

10.4161/onci.26620

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic success of immunotherapy requires specific alterations of the tumor microenvironment and/or the inhibition of tumor-elicited immunosuppression. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment. We have recently shown that modulating TAMs dramatically augments the efficacy of immunotherapy. TAM-activating agents should hence be considered as an addition to immunotherapy in future clinical trials.

引用

页数：3

共 10 条

[1] Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid [J].

Conlon, Joseph ;

Burdette, Dara L. ;

Sharma, Shruti ;

Bhat, Numana ;

Thompson, Mikayla ;

Jiang, Zhaozhao ;

Rathinam, Vijay A. K. ;

Monks, Brian ;

Jin, Tengchuan ;

Xiao, T. Sam ;

Vogel, Stefanie N. ;

Vance, Russell E. ;

Fitzgerald, Katherine A. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (10) :5216-5225

[2] Molecular origins of cancer - Cancer immunology [J].

Finn, Olivera J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (25) :2704-2715

[3] Using macrophage activation to augment immunotherapy of established tumours [J].

Fridlender, Z. G. ;

Jassar, A. ;

Mishalian, I. ;

Wang, L-C S. ;

Kapoor, V. ;

Cheng, G. ;

Sun, J. ;

Singhal, S. ;

Levy, L. ;

Albelda, S. M. .

BRITISH JOURNAL OF CANCER, 2013, 108 (06) :1288-1297

[4] Dissection of stromal and cancer cell-derived signals in melanoma xenografts before and after treatment with DMXAA [J].

Henare, K. ;

Wang, L. ;

Wang, L-C S. ;

Thomsen, L. ;

Tijono, S. ;

Chen, C-J J. ;

Winkler, S. ;

Dunbar, P. R. ;

Print, C. ;

Ching, L-M .

BRITISH JOURNAL OF CANCER, 2012, 106 (06) :1134-1147

[5] Activation of tumor-associated macrophages by the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid induces an effective CD8+ T-cell-mediated antitumor immune response in murine models of lung cancer and mesothelioma [J].

Jassar, AS ;

Suzuki, E ;

Kapoor, V ;

Sun, J ;

Silverberg, MB ;

Cheung, LM ;

Burdick, MD ;

Strieter, RM ;

Ching, LM ;

Kaiser, LR ;

Albelda, SM .

CANCER RESEARCH, 2005, 65 (24) :11752-11761

[6] Immunotherapy of cancer in 2012 [J].

Kirkwood, John M. ;

Butterfield, Lisa H. ;

Tarhini, Ahmad A. ;

Zarour, Hassane ;

Kalinski, Pawel ;

Ferrone, Soldano .

CA-A CANCER JOURNAL FOR CLINICIANS, 2012, 62 (05) :309-335

[7] Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non-Small-Cell Lung Cancer [J].

Lara, Primo N., Jr. ;

Douillard, Jean-Yves ;

Nakagawa, Kazuhiko ;

von Pawel, Joachim ;

McKeage, Mark J. ;

Albert, Istvan ;

Losonczy, Gyoergy ;

Reck, Martin ;

Heo, Dae-Seog ;

Fan, Xiaolin ;

Fandi, Abderrahim ;

Scagliotti, Giorgio .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (22) :2965-2971

[8] Cancer-promoting tumor-associated macrophages: New vistas and open questions [J].

Mantovani, Alberto ;

Germano, Giovanni ;

Marchesi, Federica ;

Locatelli, Marco ;

Biswas, Subhra K. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (09) :2522-2525

[9] 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential [J].

Prantner, Daniel ;

Perkins, Darren J. ;

Lai, Wendy ;

Williams, Mark S. ;

Sharma, Shruti ;

Fitzgerald, Katherine A. ;

Vogel, Stefanie N. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (47) :39776-39788

[10] Targeting tumour-associated macrophages [J].

Sica, Antonio ;

Rubino, Luca ;

Mancino, Alessandra ;

Larghi, Paola ;

Porta, Chiara ;

Rimoldi, Monica ;

Solinas, Graziella ;

Locati, Massimo ;

Allavena, Paola ;

Mantovani, Alberto .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (09) :1219-1229

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