Prevalence and risk factors for infection of bovine tuberculosis in indigenous cattle in the Serengeti ecosystem, Tanzania

被引:36
作者
Katale, Bugwesa Z. [1 ,2 ]
Mbugi, Erasto V. [1 ]
Karimuribo, Esron D. [3 ]
Keyyu, Julius D. [2 ]
Kendall, Sharon [4 ]
Kibiki, Gibson S. [5 ]
Godfrey-Faussett, Peter [6 ]
Michel, Anita L. [7 ]
Kazwala, Rudovick R. [3 ]
van Helden, Paul [8 ]
Matee, Mecky I. [1 ]
机构
[1] MUHAS, Sch Med, Dept Microbiol & Immunol, Dar Es Salaam, Tanzania
[2] Tanzania Wildlife Res Inst TAWIRI, Arusha, Tanzania
[3] Sokoine Univ Agr, Fac Vet Med, Dept Vet Med & Publ Hlth, Morogoro, Tanzania
[4] RVC, Ctr Emerging Endem & Exot Dis, Hatfield AL9 7TA, Herts, England
[5] Tumaini Univ, KCRI, Kilimanjaro Christian Med Coll, Moshi, Tanzania
[6] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[7] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, South Africa
[8] Univ Stellenbosch, DST NRF Ctr Excellence Biomed TB Res, Div Mol Biol & Human Genet,Fac Hlth Sci, MRC,Ctr Mol & Cellular Biol, ZA-7505 Tygerberg, Capetown, South Africa
基金
英国惠康基金;
关键词
Risk factors; Bovine tuberculosis; Mycobacterium bovis; Human-animal interface; Serengeti ecosystem; Wildlife; LIVESTOCK/WILDLIFE INTERFACE AREAS; MYCOBACTERIUM-BOVIS; SOUTHERN HIGHLANDS; EPIDEMIOLOGY; DISTRICTS; WILDLIFE; FARMS; ZONE; MILK;
D O I
10.1186/1746-6148-9-267
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background: Bovine tuberculosis (bTB) is a chronic debilitating disease and is a cause of morbidity and mortality in livestock, wildlife and humans. This study estimated the prevalence and risk factors associated with bovine tuberculosis transmission in indigenous cattle at the human-animal interface in the Serengeti ecosystem of Tanzania. Results: A total of 1,103 indigenous cattle from 32 herds were investigated for the presence of bTB using the Single Intradermal Comparative Tuberculin Test. Epidemiological data on herd structure, management and grazing system were also collected. The apparent individual animal prevalence of tuberculin reactors was 2.4% (95% confidence interval (CI), 1.7 - 3.5%), whereas the true prevalence was 0.6% CI, 0.6 - 0.7% as indicated by a reaction to avian tuberculin purified protein derivatives (PPD) which is more than 4 mm greater than the reaction to avian tuberculin PPD. The results showed that 10.6% (117/1,103) showed non-specific reactions (atypical mycobacterium). The herd prevalence of 50% (16/32) was found. Tuberculin skin test results were found to be significantly associated with age, location, size of the household and animal tested. Of 108 respondents, 70 (64.8%) individuals had not heard about bovine tuberculosis at all. Thirty five percent (38/108) of respondents at least were aware of bTB. About 60% (23/38) of respondents who were aware of bTB had some knowledge on how bTB is spread. Eighty one percent (87/108) of respondents were not aware of the presence of bTB in wildlife. There is regular contact between cattle and wild animals due to sharing of grazing land and water sources, with 99% (107/108) of households grazing cattle in communal pastures. Conclusion: The study has demonstrated a high reported interaction of livestock with wildlife and poor knowledge of most cattle owners concerning bTB and its transmission pathways among people, livestock and wildlife. Although the overall proportion of animals with bTB is relatively low, herd prevalence is 50% and prevalence within herds varied considerably. Thus there is a possibility of cross transmission of bTB at wildlife-livestock interface areas that necessitates use of genetic strain typing methods to characterize them accurately.
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页数:11
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