Enantioselective 1,4-addition of kojic acid derivatives to β-nitroolefins catalyzed by a cinchonine derived sugar thiourea

被引：21

作者：

Reddy, B. V. Subba ^{[1
]}

Reddy, S. Madhusudana ^{[1
]}

Swain, Manisha ^{[1
]}

Dudem, Srikanth ^{[2
]}

Kalivendi, Shasi V. ^{[2
]}

Reddy, C. Suresh ^{[3
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500607, Andhra Pradesh, India

[3] Sri Venkateswra Univ, Dept Chem, Tirupati, Andhra Pradesh, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 18期

关键词：

MICHAEL ADDITION; CONJUGATE ADDITION; TUMOR PROMOTERS; CHALCONES; DESIGN; AMIDE;

D O I：

10.1039/c3ra47423b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective Michael addition reaction of kojic acid derivatives to beta-nitroolefins has been accomplished using a cinchonine derived sugar thiourea. The reaction provides the corresponding Michael adducts in excellent yields with a high degree of enantioselectivity (up to 99% ee) in short reaction time with low catalyst loading. The Michael adducts are found to exhibit promising cytotoxicity against various cancer cell lines.

引用

页码：9107 / 9111

页数：5

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