Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+myeloid dendritic cells and FoxP3+T cells compared to immunocompetent controls

被引：5

作者：

Sandvik, L. F. ^{[1
,2
]}

Skarstein, K. ^{[3
]}

Krynitz, B. ^{[4
]}

Volchenkov, R. ^{[1
]}

Sviland, L. ^{[3
,5
]}

Leivestad, T. ^{[6
]}

Jonsson, R. ^{[1
]}

Appel, S. ^{[1
]}

机构：

[1] Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway

[2] Haukeland Hosp, Dept Dermatol, N-5021 Bergen, Norway

[3] Univ Bergen, Dept Clin Med, Sect Pathol, Bergen, Norway

[4] Karolinska Univ Labs, Dept Pathol & Cytol, Stockholm, Sweden

[5] Haukeland Hosp, Dept Pathol, N-5021 Bergen, Norway

[6] Oslo Univ Hosp, Rikshosp, Dept Transplantat Med, Norwegian Renal Registry, Oslo, Norway

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2015年 / 29卷 / 11期

关键词：

HUMAN T-CELLS; SKIN-CANCER; LANGERHANS CELLS; CLINICOPATHOLOGICAL FEATURES; EXPRESSION; TARGETS; KIDNEY;

D O I：

10.1111/jdv.13151

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BackgroundRenal transplant recipients (RTR) have an increased risk of developing cutaneous squamous cell carcinomas (SCC). These SCC are often more aggressive than SCC in immunocompetent individuals. ObjectivesIn this comparative study, we analysed the cell composition in the tissue immediately surrounding invasive SCC in immunosuppressed RTR and immunocompetent controls in an effort to further elucidate the role of the local immune system. MethodsMorphology and quantity of various dendritic cell (DC) subsets, macrophages and FoxP3+ T cells were analysed by immunohistochemical staining. ResultsThe number of CD11c+ myeloid DC and FoxP3+ T cells was significantly reduced in RTR, whereas the number of plasmacytoid DC, Langerhans cells and macrophages was similar in RTR and controls. ConclusionsA reduction in CD11c+ mDC in peritumoral dermis in RTR might contribute to impaired immunosurveillance thus giving rise to an increased risk to develop aggressive SCC in these patients.

引用

页码：2128 / 2135

页数：8

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