The JAK-STAT pathway in Drosophila

被引：54
作者：
Hou, XS
Perrimon, N
机构：
[1] Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston
来源：
TRENDS IN GENETICS | 1997年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0168-9525(97)01006-8
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent studies in Drosophila have identified a single JAK and a single STAT protein. Genetic and biochemical analyses reveal that these two proteins operate in the same signal transduction pathway. phenotypic analyses of JAK and STAT mutants implicate this pathway in a number of developmental decisions, in particular the regulation of pair-rule genes and fly hematopoiesis.
引用
收藏
页码：105 / 110
页数：6
相关论文
共 34 条
[21]  
PERRIMON N, IN PRESS GENETICS
[22]   TRANSCRIPTIONAL RESPONSES TO POLYPEPTIPE LIGANDS - THE JAK-STAT PATHWAY [J].
SCHINDLER, C ;
DARNELL, JE .
ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :621-651
[23]   RAS1 AND A PUTATIVE GUANINE-NUCLEOTIDE EXCHANGE FACTOR PERFORM CRUCIAL STEPS IN SIGNALING BY THE SEVENLESS PROTEIN TYROSINE KINASE [J].
SIMON, MA ;
BOWTELL, DDL ;
DODSON, GS ;
LAVERTY, TR ;
RUBIN, GM .
CELL, 1991, 67 (04) :701-716
[24]   Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo [J].
Small, S ;
Blair, A ;
Levine, M .
DEVELOPMENTAL BIOLOGY, 1996, 175 (02) :314-324
[25]  
STJOHNSTON D, 1992, CELL, V68, P201
[26]   CYTOKINE SIGNALING THROUGH NONRECEPTOR PROTEIN-TYROSINE KINASES [J].
TANIGUCHI, T .
SCIENCE, 1995, 268 (5208) :251-255
[27]   Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells [J].
Thierfelder, WE ;
vanDeursen, JM ;
Yamamoto, K ;
Tripp, RA ;
Sarawar, SR ;
Carson, RT ;
Sangster, MY ;
Vignali, DAA ;
Doherty, PC ;
Grosveld, GC ;
Ihle, JN .
NATURE, 1996, 382 (6587) :171-174
[28]   DEFECTS IN B-LYMPHOCYTE MATURATION AND T-LYMPHOCYTE ACTIVATION IN MICE LACKING JAK3 [J].
THOMIS, DC ;
GURNIAK, CB ;
TIVOL, E ;
SHARPE, AH ;
BERG, LJ .
SCIENCE, 1995, 270 (5237) :794-797
[29]  
WATSON KL, 1994, J CELL SCI S, V18, P19
[30]   MAXIMAL ACTIVATION OF TRANSCRIPTION BY STAT1 AND STAT3 REQUIRES BOTH TYROSINE AND SERINE PHOSPHORYLATION [J].
WEN, ZL ;
ZHONG, Z ;
DARNELL, JE .
CELL, 1995, 82 (02) :241-250
1234