Influence of agglomeration of cohesive particles on the dissolution behaviour of furosemide powder

The objective of this particular study was to describe a method whereby the dissolution rate of a powder may be calculated from its mean weighted particle size distribution. This method was used to determine the effect of particle size, powder agglomeration and methods used to disperse powder agglomerates on dissolution behaviour. In particular, the dissolution rates of agglomerates and dispersed particles of furosemide powders with different particle size distributions were studied. Provided the particle size distribution of the particles, or agglomerates, in the dissolution medium was known, simulated dissolution profiles agreed with measured dissolution profiles. Results showed that microfine furosemide powder with a mean volume particle size of 3 mu m was agglomerated to such an extent that the dissolution of this powder was never equal to that of single particles. Even strong, forceful methods such as interactive mixing and sonication in a surfactant solution did not completely disperse this powder.