Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib

被引:201
作者
Jackman, David M. [1 ]
Holmes, Alison J.
Lindeman, Neal
Wen, Patrick Y.
Kesari, Santosh
Borras, Ana M.
Bailey, Christopher
de Jong, Francisca
Jaenne, Pasi A.
Johnson, Bruce E.
机构
[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
[5] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA
[6] Dana Farber Canc Inst, Transplant Res Lab, Boston, MA 02115 USA
[7] AstraZeneca, Dept Drug Metab & Pharmacokinet, Macclesfield, Cheshire, England
[8] Analyt Medinet BV, Breda, Netherlands
关键词
D O I
10.1200/JCO.2006.06.6126
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:4517 / 4520
页数:4
相关论文
共 10 条
[1]   Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types [J].
Baselga, J ;
Rischin, D ;
Ranson, M ;
Calvert, H ;
Raymond, E ;
Kieback, DG ;
Kaye, SB ;
Gianni, L ;
Harris, A ;
Bjork, T ;
Averbuch, SD ;
Feyereislova, A ;
Swaisland, H ;
Rojo, F ;
Albanell, J .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (21) :4292-4302
[2]   A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening [J].
Jänne, PA ;
Borras, AM ;
Kuang, YN ;
Rogers, AM ;
Joshi, VA ;
Liyanage, H ;
Lindeman, N ;
Lee, JC ;
Halmos, B ;
Maher, EA ;
Distel, RJ ;
Meyerson, M ;
Johnson, BE .
CLINICAL CANCER RESEARCH, 2006, 12 (03) :751-758
[3]   A sensitive assay for ZD1839 (Iressa) in human plasma by liquid-liquid extraction and high performance liquid chromatography with mass spectrometric detection: validation and use in Phase I clinical trials [J].
Jones, HK ;
Stafford, LE ;
Swaisland, HC ;
Payne, R .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2002, 29 (1-2) :221-228
[4]   EGFR mutation and resistance of non-small-cell lung cancer to gefitinib [J].
Kobayashi, S ;
Boggon, TJ ;
Dayaram, T ;
Janne, PA ;
Kocher, O ;
Meyerson, M ;
Johnson, BE ;
Eck, MJ ;
Tenen, DG ;
Halmos, B .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :786-792
[5]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[6]   Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations [J].
Mukohara, T ;
Engelman, JA ;
Hanna, NH ;
Yeap, BY ;
Kobayashi, S ;
Lindeman, N ;
Halmos, B ;
Pearlberg, J ;
Tsuchihashi, Z ;
Cantley, LC ;
Tenen, DG ;
Johnson, BE ;
Jänne, PA .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (16) :1185-1194
[7]   Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors [J].
Nakagawa, K ;
Tamura, T ;
Negoro, S ;
Kudoh, S ;
Yamamoto, N ;
Yamamoto, N ;
Takeda, K ;
Swaisland, H ;
Nakatani, I ;
Hirose, M ;
Dong, RP ;
Fukuoka, M .
ANNALS OF ONCOLOGY, 2003, 14 (06) :922-930
[8]   High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib [J].
Omuro, AMP ;
Kris, MG ;
Miller, VA ;
Franceschi, E ;
Shah, N ;
Milton, DT ;
Abrey, LE .
CANCER, 2005, 103 (11) :2344-2348
[9]   EGFR mutations in lung cancer:: Correlation with clinical response to gefitinib therapy [J].
Paez, JG ;
Jänne, PA ;
Lee, JC ;
Tracy, S ;
Greulich, H ;
Gabriel, S ;
Herman, P ;
Kaye, FJ ;
Lindeman, N ;
Boggon, TJ ;
Naoki, K ;
Sasaki, H ;
Fujii, Y ;
Eck, MJ ;
Sellers, WR ;
Johnson, BE ;
Meyerson, M .
SCIENCE, 2004, 304 (5676) :1497-1500
[10]   Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain [J].
Pao, W ;
Miller, VA ;
Politi, KA ;
Riely, GJ ;
Somwar, R ;
Zakowski, MF ;
Kris, MG ;
Varmus, H .
PLOS MEDICINE, 2005, 2 (03) :225-235