Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?

被引：79

作者：

Krueger, Thilo ^{[1
]}

Westenfeld, Ralf ^{[2
]}

Ketteler, Markus ^{[3
]}

Schurgers, Leon J. ^{[4
]}

Floege, Juergen ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, Univ Hosp, Aachen, Germany

[2] Rhein Westfal TH Aachen, Div Cardiol, Univ Hosp, Aachen, Germany

[3] Hosp Coburg, Div Nephrol, Coburg, Germany

[4] Univ Maastricht, Cardiovasc Res Inst & VitaK, Maastricht, Netherlands

来源：

KIDNEY INTERNATIONAL | 2009年 / 76卷 / 01期

关键词：

dialysis; Matrix Gla protein; vascular calcification; vitamin K; MATRIX GLA-PROTEIN; SMOOTH-MUSCLE-CELLS; HEMODIALYSIS-PATIENTS; POSTMENOPAUSAL WOMEN; BONE LOSS; ARTERY CALCIFICATION; MEDIA CALCIFICATION; RENAL-FAILURE; FRACTURES; WARFARIN;

D O I：

10.1038/ki.2009.126

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this review is to summarize currently available evidence implicating vitamin K in the pathogenesis of vascular calcification (VC), in particular arterial medial calcification. In doing so, we try to provide a rationale for an interventional clinical study testing whether vitamin K supplementation can retard VC or even affect cardiovascular mortality in chronic kidney disease patients. Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population. Kidney International (2009) 76, 18-22; doi: 10.1038/ki.2009.126; published online 22 April 2009

引用

页码：18 / 22

页数：5

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