Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts of Beta vulgaris var. cicla

被引：43

作者：

Kim, I

Chin, YW

Lim, SW

Kim, YC

Kim, J ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 06期

关键词：

Beta vulgaris var. cicla; hepatoprotective activity; flavonoid; (+)-dehydrovomifoliol; 3-hydroxy-5; alpha; 6; alpha-epoxy-beta-ionone; vitexin; 7-O-beta-D-glucopyranoside; vitexin 2 ''-O-beta-D-glucopyranoside;

D O I：

10.1007/BF02980156

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(+)-Dehydrovomifoliol (1), 3-hydroxy-5alpha,6alpha-epoxy-beta-ionone (2), vitexin 7-O-beta-D-glucopyranoside (3), and vitexin 2"-O-beta-D-glucopyranoside (4) were isolated as new constituents from the aerial parts of Beta vulgaris var. cicla. Compounds 3 and 4 demonstrated hepatoprotective activity with values of 65.8 and 56.1%, respectively, in primary cultured rat hepatocytes with CCl4-induced cell toxicity, compared to controls. This was comparable to that of silibinin (69.8 %) which was used as a positive control.

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页码：600 / 603

页数：4

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