A catalyst- and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction

被引：16

作者：

Dongare, Sakharam B. ^{[1
]}

Chavan, Hemant V. ^{[2
]}

Bhale, Pravin S. ^{[1
]}

Mule, Yoginath B. ^{[1
]}

Kotmale, Amol S. ^{[1
]}

Bandgar, Babasaheb P. ^{[1
]}

机构：

[1] Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India

[2] ASP Coll, Dept Chem, Dist Ratnagiri 415804, Maharashtra, India

来源：

CHINESE CHEMICAL LETTERS | 2016年 / 27卷 / 01期

关键词：

Bioisosters; 7-Azaindole; Mannich reaction; Multicomponent reaction; 3-AMINOALKYLATED INDOLES; ONE-POT; COMPONENT SYNTHESIS; PRACTICAL SYNTHESIS; EFFICIENT; DERIVATIVES; 7-AZAINDOLE; AZAINDOLES; INHIBITORS; ALKALOIDS;

D O I：

10.1016/j.cclet.2015.07.029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by H-1 NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：99 / 103

页数：5

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