An innovative CCD-based high-resolution CT system for analysis of trabecular bone tissue

被引:10
作者
Baruffaldi, F. [1 ]
Beituzzi, M.
Bianconi, D.
Brancaccio, R.
Cornacchia, S.
Lanconelli, N.
Mancini, L.
Morigi, M. P.
Pasini, A.
Perilli, E.
Romani, D.
Rossi, A.
Casali, E.
机构
[1] Ist Ortoped Rizzoli, Lab Tecnol Med, I-40136 Bologna, Italy
[2] Univ Bologna, Dept Phys, I-40127 Bologna, Italy
[3] Ist Nazl Fis Nucl, I-40127 Bologna, Italy
[4] Trieste SCpA, I-34012 Trieste, Italy
[5] Univ Bologna, Dept Elect Comp Sci & Syst, I-40136 Bologna, Italy
关键词
biomedical; X-ray detectors; X-ray tomography;
D O I
10.1109/TNS.2006.876047
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Synchrotron-based digital radiography and microtomography devices are powerful, nondestructive, high-resolution research tools. In this paper, we present a linear system with a pixel size of 22.5 mu m and a field-of-view (FOV) 13 cm long and about 1 mm high. The system is composed of a linear converter GOS screen coupled to an intensified electron-bombarded CCD (EBCCD) camera, by means of a rectangular-to-linear fiber optic adapter. This optical guide is composed of seven bundles, each one transporting light in a coherent way to preserve spatial information. In this way, a high spatial resolution over an extended FOV is obtained. The detector works as an X-ray scanner by means of a high-precision translation mechanical device with 18 cm travel range. The total FOV obtained this way is 13 cm long and 18 cm high. The aim of this paper is to demonstrate the feasibility of this system to investigate a large area of a bone and to calculate the appropriate histomorphometric parameters. Here we present an investigation gained at ELETTRA synchrotron facility at Trieste, Italy. A monochromatic 34-keV beam has been used for imaging a human proximal femur, about 9 cm in width, with our system. The reconstructed images (13 cm x 13 cm) were cross sections containing femoral head, femoral neck, and greater trochanter. The local variations in trabecular and cortical structure of the examined bone were clearly visible at a level not obtainable with medical CT scanners. The used spatial resolution allowed the visualization of thin trabeculae, which typically lie in a range of 100 mu m or lower. The quality of the reconstructed cross-section images confirmed that the system presented is a novel tool for high resolution three-dimensional (3-D) imaging of bone structure, with a pixel size over a volume of interest not achievable with conventional microCT scanners.
引用
收藏
页码:2584 / 2590
页数:7
相关论文
共 34 条
[11]   THE DIRECT EXAMINATION OF 3-DIMENSIONAL BONE ARCHITECTURE INVITRO BY COMPUTED-TOMOGRAPHY [J].
FELDKAMP, LA ;
GOLDSTEIN, SA ;
PARFITT, AM ;
JESION, G ;
KLEEREKOPER, M .
JOURNAL OF BONE AND MINERAL RESEARCH, 1989, 4 (01) :3-11
[12]   THE RELATIONSHIP BETWEEN THE STRUCTURAL AND ORTHOGONAL COMPRESSIVE PROPERTIES OF TRABECULAR BONE [J].
GOULET, RW ;
GOLDSTEIN, SA ;
CIARELLI, MJ ;
KUHN, JL ;
BROWN, MB ;
FELDKAMP, LA .
JOURNAL OF BIOMECHANICS, 1994, 27 (04) :375-389
[13]   Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level [J].
Homminga, J ;
McCreadie, BR ;
Ciarelli, TE ;
Weinans, H ;
Goldstein, SA ;
Huiskes, R .
BONE, 2002, 30 (05) :759-764
[14]   Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: I. Two-dimensional histology [J].
Hordon, LD ;
Raisi, M ;
Aaron, JE ;
Paxton, SK ;
Beneton, M ;
Kanis, JA .
BONE, 2000, 27 (02) :271-276
[15]   AGE AND BONE MASS AS PREDICTORS OF FRACTURE IN A PROSPECTIVE-STUDY [J].
HUI, SL ;
SLEMENDA, CW ;
JOHNSTON, CC .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (06) :1804-1809
[16]   The relationship between three-dimensional connectivity and the elastic properties of trabecular bone [J].
Kinney, JH ;
Ladd, AJC .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (05) :839-845
[17]   EVALUATION OF A MICROCOMPUTED TOMOGRAPHY SYSTEM TO STUDY TRABECULAR BONE-STRUCTURE [J].
KUHN, JL ;
GOLDSTEIN, SA ;
FELDKAMP, LA ;
GOULET, RW ;
JESION, G .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1990, 8 (06) :833-842
[18]   Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis [J].
Legrand, E ;
Chappard, D ;
Pascaretti, C ;
Duquenne, M ;
Krebs, S ;
Rohmer, V ;
Basle, MF ;
Audran, M .
JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (01) :13-19
[19]   Biomechanics of fracture: Is bone mineral density sufficient to assess risk? [J].
McCreadie, BR ;
Goldstein, SA .
JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (12) :2305-2308
[20]   EPIDEMIOLOGY OF VERTEBRAL FRACTURES IN WOMEN [J].
MELTON, LJ ;
KAN, SH ;
FRYE, MA ;
WAHNER, HW ;
OFALLON, WM ;
RIGGS, BL .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 129 (05) :1000-1011