Synthesis of peptidomimetics containing a β-lactam moiety using peptidic diazoketones and imines in a Staudinger reaction

被引：42

作者：

Linder, MR ^{[1
]}

Podlech, J ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1021/ol9908171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Rearrangement of alpha-amino acid or oligopeptide derived diazoketones in the presence of N-benzylbenzaldimine, alpha- amino acid, or tripeptide derived imines, respectively, led to peptidyl-substituted beta-lactams. The trans-substituted diastereoisomers are formed exclusively.

引用

页码：869 / 871

页数：3

共 35 条

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