Clinical characteristics of women with reproductive cycle-associated bipolar disorder symptoms

被引:31
作者
Perich, Tania A. [1 ,2 ,3 ]
Roberts, Gloria [1 ,2 ]
Frankland, Andrew [1 ,2 ]
Sinbandhit, Carina [1 ,2 ]
Meade, Tanya [3 ]
Austin, Marie-Paul [1 ,2 ]
Mitchell, Philip B. [1 ,2 ]
机构
[1] Univ New South Wales, Sch Psychiat, Randwick, NSW 2031, Australia
[2] Black Dog Inst, Randwick, NSW, Australia
[3] Univ Western Sydney, Sch Social Sci & Psychol, Clin & Hlth Psychol Res Initiat CaHPRI, Penrith, NSW, Australia
基金
英国医学研究理事会;
关键词
Bipolar disorder; menopause; postnatal; premenstrual; hormonal mood changes; GENDER-DIFFERENCES; MENSTRUAL-CYCLE; DEPRESSION; EVENTS; SAMPLE; MOOD;
D O I
10.1177/0004867416670015
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Although there is clear evidence that reproductive cycle events are associated with mood episodes for women with bipolar disorder, few studies have examined for relationships between these and specific clinical characteristics of the disorder. This study aimed to explore the relationship between mood symptoms associated with reproductive cycle events and features of the disorder indicative of a more severe lifetime course. Method: Totally, 158 women of at least 18 years of age participated in the study. Subjects were recruited through a specialist clinic at the Black Dog Institute, Sydney, Australia. Results: In total, 77% of women reported increases in mood symptoms during perimenstrual, postnatal or menopausal periods. These women had an earlier age of onset for depressive and hypo/manic episodes and a greater likelihood of comorbid anxiety disorders, rapid cycling and mixed mood compared to those who did not report such reproductive cycle-associated mood changes. Women who experienced postnatal episodes were also more likely to experience worse mood symptoms perimenstrually and menopausally. Conclusion: First, reproductive cycle event-related worsening of mood was associated with a more severe lifetime course of bipolar disorder, and, second, it appears that some women have a greater propensity to mood worsening at each of these reproductive cycle events. If replicated, these findings provide important information for clinicians treating women with reproductive cycle event mood changes and highlight the need for improved therapeutics for such presentations.
引用
收藏
页码:161 / 167
页数:7
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