Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder

被引:40
作者
Chao, Linda L. [1 ,2 ,3 ]
Tosun, Duygu [1 ,2 ]
Woodward, Steven H.
Kaufer, Daniela [4 ,5 ,6 ]
Neylan, Thomas C. [3 ,7 ]
机构
[1] Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USA
[2] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
[4] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
[5] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA
[6] Canadian Inst Adv Res CIFAR, Toronto, ON, Canada
[7] Vet Affairs Med Ctr, Mental Hlth Serv, San Francisco, CA 94121 USA
来源
FRONTIERS IN BEHAVIORAL NEUROSCIENCE | 2015年 / 9卷
关键词
myelin; hippocampus; post-traumatic stress disorder; imaging; plasticity; MILD COGNITIVE IMPAIRMENT; WHITE-MATTER INTEGRITY; PROTEOLIPID PROTEIN; BASIC-PROTEIN; AXON GROWTH; DIFFUSION; GLUCOCORTICOIDS; CORTEX; GENES; BRAIN;
D O I
10.3389/fnbeh.2015.00333
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recent findings suggest the formation of myelin in the central nervous system by oligodendrocytes is a continuous process that can be modified with experience. For example, a recent study showed that immobilization stress increased oligodendrogensis in the dentate gyrus of adult rat hippocampus. Because changes in myelination represents an adaptive form of brain plasticity that has a greater reach in the adult brain than other forms of plasticity (e.g., neurogenesis), the objective of this "proof of concept" study was to examine whether there are differences in myelination in the hippocampi of humans with and without post-traumatic stress disorder (PTSD). We used the ratio of T1-weighted/T2-weighted magnetic resonance image (MRI) intensity to estimate the degree of hippocampal myelination in 19 male veterans with PTSD and 19 matched trauma-exposed male veterans without PTSD (mean age: 43 12 years). We found that veterans with PTSD had significantly more hippocampal myelin than trauma exposed controls. There was also found a positive correlation between estimates of hippocampal myelination and PTSD and depressive symptom severity. To our knowledge, this is the first study to examine hippocampal myelination in humans with PTSD. These results provide preliminary evidence for stress induced hippocampal myelin formation as a potential mechanism underlying the brain abnormalities associated with vulnerability to stress.
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页数:8
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