Future clinical implications emerging from recent genome-wide expression studies in asthma

被引：9
作者：
Berube, Jean-Christophe [1 ]
Bosse, Yohan [1 ,2 ]
机构：
[1] Inst Univ Cardiol & Pneumol Quebec, Ste Foy, PQ G1V 4G5, Canada
[2] Univ Laval, Dept Mol Med, Quebec City, PQ, Canada
来源：
EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2014年 / 10卷 / 08期
基金：
加拿大健康研究院;
关键词：
asthma; biomarkers; gene expression profiling; predictive testing; transcriptomics; AIRWAY SMOOTH-MUSCLE; DIFFERENTIAL GENE-EXPRESSION; BLOOD MONONUCLEAR-CELLS; BITTER TASTE RECEPTORS; ALLERGIC-ASTHMA; ANIMAL-MODELS; RNA-SEQ; CHILDHOOD ASTHMA; CANDIDATE GENES; UP-REGULATION;
D O I：
10.1586/1744666X.2014.932249
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Host susceptibility to environmental triggers is the most likely explanation for the development of asthma. Quantifying gene expression levels in disease-relevant tissues and cell types using fast evolving genomic technologies have generated new hypotheses about the pathogenesis of asthma and identified new therapeutic targets to treat asthma and asthma-exacerbations. New biomarkers and distinct transcriptomic phenotypes in blood, sputum and other tissues were also identified and proved effective to refine asthma classification and guide targeted therapies. The wealth of information provided by transcriptomic studies in asthma is yet to be fully exploited, but discoveries in this field may soon be implemented in clinical settings to improve diagnosis and treatment of patients afflicted with this common disease.
引用
收藏
页码：985 / 1004
页数：20
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