Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis

被引：20
作者：
Benedek, Annabella [1 ]
Cernica, Daniel [1 ]
Mester, Andras [1 ]
Opincariu, Diana [1 ]
Hodas, Roxana [1 ]
Rodean, Ioana [1 ]
Keri, Johanna [1 ]
Benedek, Theodora [1 ]
机构：
[1] Univ Med & Pharm, Cardiac Crit Care Unit, Clin Cardiol, Gheorghe Marinescu 38, Targu Mures 540139, Romania
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 10期
关键词：
ischemic stroke; endothelial shear stress; neuroprotection; neuroregeneration; 3D-bioprinted scaffolds; stem cells; regenerative therapy; ENDOTHELIAL PROGENITOR CELLS; MARROW MONONUCLEAR-CELLS; COMPUTATIONAL FLUID-DYNAMICS; FOCAL CEREBRAL-ISCHEMIA; NEURAL PRECURSOR CELLS; GROWTH-FACTOR; FUNCTIONAL RECOVERY; NERVOUS-SYSTEM; INTRAVENOUS TRANSPLANTATION; VASCULAR-PERMEABILITY;
D O I：
10.3390/ijms20102574
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ischemic stroke is associated with a tremendous economic and societal burden, and only a few therapies are currently available for the treatment of this devastating disease. The main therapeutic approaches used nowadays for the treatment of ischemic brain injury aim to achieve reperfusion, neuroprotection and neurorecovery. Therapeutic angiogenesis also seems to represent a promising tool to improve the prognosis of cerebral ischemia. This review aims to present the modern concepts and the current status of regenerative therapy for ischemic stroke and discuss the main results of major clinical trials addressing the effectiveness of stem cell therapy for achieving neuroregeneration in ischemic stroke. At the same time, as a glimpse into the future, this article describes modern concepts for stroke prevention, such as the implantation of bioprinted scaffolds seeded with stem cells, whose 3D geometry is customized according to carotid shear stress.
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页数：25
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