Tiagabine and nonconvulsive status epilepticus

被引：0

作者：

Holtkamp, M ^{[1
]}

Pfeiffer, M ^{[1
]}

Buchheim, K ^{[1
]}

Meierkord, H ^{[1
]}

机构：

[1] Neurol Klin & Poliklin, D-10117 Berlin, Germany

来源：

NERVENARZT | 1999年 / 70卷 / 12期

关键词：

tiagabine; status epilepticus; GABAergic inhibition;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

a case report is given to draw attention to the risk of the occurence of nonconvulsive status epilepticus (NCSE) under the anticonvulsant tiagabine in higher doses and dosis increases. The patient who had no previous history of status epilepticus developed several NCSE shortly after administration of tiagabine. This represents strong evidence of a causal relationship. Also, in experimental studies it has been shown that in higher doses a disequilibrium between glial and neuronal GABA uptake may aggravate the failure of GABA inhibition thus explaining this adverse side-effect.

引用

页码：1104 / 1106

页数：3

共 7 条

[1] Nonconvulsive status epilepticus in two patients receiving tiagabine treatment [J].