RCC Immune Microenvironment Subsequent to Targeted Therapy: A Friend or a Foe?
被引:10
作者:
Chen, Wenjin
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机构:
Second Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R ChinaSecond Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R China
Chen, Wenjin
[1
]
Pan, Xiuwu
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机构:
Second Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R ChinaSecond Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R China
Pan, Xiuwu
[1
]
Cui, Xingang
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机构:
Second Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R ChinaSecond Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R China
Cui, Xingang
[1
]
机构:
[1] Second Mil Med Univ, Dept Urol, Affiliated Hosp 3, Shanghai, Peoples R China
Renal cell carcinoma (RCC) is composed of different subtypes with distinct molecular and histological tumor heterogeneity. Although the advent of various targeted therapies has improved the survival of patients with advanced RCC over the past 15 years (since 2006), few cases experienced complete response due to drug resistance. Recent studies have demonstrated that the outcomes following targeted therapies are potentially associated with intricate cross-links between immune responses and suppressors in the tumor microenvironment (TME). In addition, progress on drug research and development enhances our awareness and understanding about immunotherapy and combined treatment. In this review article, we intend to make a comprehensive summary about TME and its alterations following targeted therapies, provide valid evidence in this aspect, and discuss optimal matches between targeted therapy and immunotherapy.
机构:
HEGP Serv Immunol Biol, AP HP, Paris, France
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Adotevi, Olivier
;
Pere, Helene
论文数: 0引用数: 0
h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, France
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Pere, Helene
;
Ravel, Patrice
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Biochim Struct, CNRS, UMR5048, Montpellier, France
INSERM, U554, Montpellier, France
Univ Montpellier 1 & 2, Montpellier, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Ravel, Patrice
;
Haicheur, Nacilla
论文数: 0引用数: 0
h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Haicheur, Nacilla
;
Badoual, Cecile
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, France
Serv Anat Pathol HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Badoual, Cecile
;
Merillon, Nathalie
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Merillon, Nathalie
;
Medioni, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Serv Oncol Med HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Medioni, Jacques
;
Peyrard, Severine
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Invest Clin, INSERM, Unite Epidemiol & Rech Clin HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Peyrard, Severine
;
Roncelin, Stephane
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机构:
HEGP Serv Immunol Biol, AP HP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Roncelin, Stephane
;
Verkarre, Virginie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Necker Enfants Malad, Serv Anat Pathol, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Verkarre, Virginie
;
Mejean, Arnaud
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h-index: 0
机构:
Serv Urol Hop Necker, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Mejean, Arnaud
;
Fridman, Wolf H.
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h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Fridman, Wolf H.
;
Oudard, Stephane
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, France
Serv Oncol Med HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Bakhtyar, Nazihah
;
Wong, Nicholas
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Wong, Nicholas
;
Kapoor, Anil
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Kapoor, Anil
;
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机构:
Cutz, Jean-Claude
;
Hill, Brianne
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Hill, Brianne
;
Ghert, Michelle
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Ghert, Michelle
;
Tang, Damu
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
机构:
HEGP Serv Immunol Biol, AP HP, Paris, France
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Adotevi, Olivier
;
Pere, Helene
论文数: 0引用数: 0
h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, France
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Pere, Helene
;
Ravel, Patrice
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Biochim Struct, CNRS, UMR5048, Montpellier, France
INSERM, U554, Montpellier, France
Univ Montpellier 1 & 2, Montpellier, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Ravel, Patrice
;
Haicheur, Nacilla
论文数: 0引用数: 0
h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Haicheur, Nacilla
;
Badoual, Cecile
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, France
Serv Anat Pathol HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Badoual, Cecile
;
Merillon, Nathalie
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Merillon, Nathalie
;
Medioni, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Serv Oncol Med HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Medioni, Jacques
;
Peyrard, Severine
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Invest Clin, INSERM, Unite Epidemiol & Rech Clin HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Peyrard, Severine
;
Roncelin, Stephane
论文数: 0引用数: 0
h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Roncelin, Stephane
;
Verkarre, Virginie
论文数: 0引用数: 0
h-index: 0
机构:
Hop Necker Enfants Malad, Serv Anat Pathol, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Verkarre, Virginie
;
Mejean, Arnaud
论文数: 0引用数: 0
h-index: 0
机构:
Serv Urol Hop Necker, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Mejean, Arnaud
;
Fridman, Wolf H.
论文数: 0引用数: 0
h-index: 0
机构:
HEGP Serv Immunol Biol, AP HP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
Fridman, Wolf H.
;
Oudard, Stephane
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U970, Paris Cardiovasc Res Ctr PARCC, Paris, France
Univ Paris 05, UMR S970, Paris, France
Serv Oncol Med HEGP, Paris, FranceHEGP Serv Immunol Biol, AP HP, Paris, France
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Bakhtyar, Nazihah
;
Wong, Nicholas
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Wong, Nicholas
;
Kapoor, Anil
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Kapoor, Anil
;
论文数: 引用数:
h-index:
机构:
Cutz, Jean-Claude
;
Hill, Brianne
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Hill, Brianne
;
Ghert, Michelle
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
Ghert, Michelle
;
Tang, Damu
论文数: 0引用数: 0
h-index: 0
机构:
St Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada
McMaster Univ, St Josephs Hosp, Dept Surg, Hamilton, ON, Canada
St Josephs Hosp, Father Sean OSullivan Res Inst, Hamilton, ON, Canada
St Josephs Hosp, Hamilton Ctr Kidney Res, Hamilton, ON, CanadaSt Josephs Hosp, Div Nephrol, Dept Med, Hamilton, ON L8N 4A6, Canada