The Effect of Allium cepa Extract on Lung Oxidant, Antioxidant, and Immunological Biomarkers in Ovalbumin- Sensitized Rats

被引:35
作者
Marefati, N. [1 ,2 ]
Eftekhar, N. [2 ]
Kaveh, M. [2 ]
Boskabadi, J. [1 ,2 ]
Beheshti, F. [2 ]
Boskabady, M. H. [1 ,2 ]
机构
[1] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Sch Med, Dept Physiol, Mashhad, Iran
关键词
Asthma; Allium cepa; Antioxidants; Immunomodulation; MURINE MODEL; GUINEA-PIGS; IN-VITRO; ASTHMA; QUERCETIN; BALANCE; L; ACTIVATION;
D O I
10.1159/000487885
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To evaluate the effects of Allium cepa (A. cepa) on levels of oxidants, antioxidants, and immunological markers in bronchoalveolar lavage fluids (BALF) of sensitized rats. Materials and Methods: Oxidant/antioxidant markers and cytokines in BALF of control rats treated with saline (group C), ovalbumin-sensitized rats (group S), rats treated with 1.25 mu g/mL dexamethasone and 3 doses of A. cepa extract (35, 70, and 140 mg/kg body weight [BW]/day) (S + AC) were investigated. Comparison of the results between groups was performed using analysis of variance with the Tukey-Kramer post hoc test. Results: The oxidant markers nitrogen dioxide (NO2), nitrate (NO3-), and malondialdehyde (MDA), and immunological markers interleukin (IL)-4 and immunoglobulin E (IgE) were significantly higher, but the antioxidant markers superoxide dismutase (SOD), catalase (CAT), thiol, and interferon (IFN)-gamma, and the IFN-gamma/IL-4 ratio were lower in sensitized rats compared to control rats (p < 0.001 to p < 0.01). Compared to group S, the levels of the following markers were significantly lower: NO2, NO3-, and IgE in groups treated with the A. cepa extract, MDA and IL-4 levels in groups treated with 70 and 140 mg/kg BW/day of the A. cepa extract, and all these markers as well as IFN-gamma in rats treated with dexamethasone (p < 0.001 to p < 0.05). However, there were significantly higher levels of SOD and CAT and an increased IFN-gamma/IL-4 ratio (groups treated with 70 and 140 mg/kg BW/day of the A. cepa extract), and levels of thiol and IFN-gamma (group treated with 140 mg/kg BW/day of the A. cepa extract) as well as SOD, CAT, and thiol (dexamethasone-treated group) versus group S (p < 0.00 to p < 0.05). Conclusion: A. cepa showed antioxidant and immunomodulatory properties in sensitized rats. (C) 2018 The Author(s) Published by S. Karger AG, Basel.
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页码:122 / 128
页数:7
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