Comparison of 3 Postthrombotic Syndrome Assessment Scales Demonstrates Significant Variability in Children and Adolescents With Deep Vein Thrombosis

被引:15
作者
Raffini, Leslie [1 ]
Davenport, Jillian [1 ]
Bevilacqua, Lisa [1 ]
Iosifescu, Sarah [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Childrens Hosp Philadelphia, Dept Pediat,Div Hematol, Philadelphia, PA 19104 USA
关键词
correlation studies; outcome assessment; pediatrics; quality of life; thrombolysis; therapeutic; TERM CLINICAL-COURSE; QUALITY-OF-LIFE; VENOUS THROMBOSIS; FACTOR-VIII; SEVERITY;
D O I
10.1097/MPH.0000000000000399
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Postthrombotic syndrome (PTS) is an important outcome in children with deep vein thrombosis (DVT). There are several instruments to measure PTS, and no accepted gold standard. The objective of this cross-sectional prospective study was to compare the prevalence of PTS in patients above 8 years old with a history of DVT using 3 scales: the Villalta scale, a pediatric modification of the Villalta scale, and the Manco-Johnson instrument. Forty-four subjects (22 females) were enrolled; mean age 16.6 years (SD 3.6 y). The majority had a lower extremity DVT. The average duration from DVT to PTS assessment was 2.6 years. The proportion of subjects with PTS using the adult Villalta scale was 11%, which was significantly less than the 66% of patients identified using both pediatric scales (P<0.0001). The majority of patients with PTS as determined by the pediatric scales had mild PTS. There was significant discordance between the prevalence of PTS using the Villalta scale compared with the 2 pediatric scales. This is especially relevant when considering which instrument to use in adolescent patients. This study demonstrates that PTS, as defined by these scales, is not a well-defined or standardized outcome, particularly when comparing adult and pediatric instruments.
引用
收藏
页码:611 / 615
页数:5
相关论文
共 28 条
[1]   VENOUS THROMBOEMBOLIC COMPLICATIONS (VTE) IN CHILDREN - FIRST ANALYSES OF THE CANADIAN REGISTRY OF VTE [J].
ANDREW, M ;
DAVID, M ;
ADAMS, M ;
ALI, K ;
ANDERSON, R ;
BARNARD, D ;
BERNSTEIN, M ;
BRISSON, L ;
CAIRNEY, B ;
DESAI, D ;
GRANT, R ;
ISRAELS, S ;
JARDINE, L ;
LUKE, B ;
MASSICOTTE, P ;
SILVA, M .
BLOOD, 1994, 83 (05) :1251-1257
[2]   Postthrombotic syndrome following upper extremity deep vein thrombosis in children [J].
Avila, Maria L. ;
Duan, Lucy ;
Cipolla, Amanda ;
Kim, Ashley ;
Kahr, Walter H. A. ;
Williams, Suzan ;
Brandao, Leonardo R. .
BLOOD, 2014, 124 (07) :1166-1173
[3]   Clinical course of postthrombotic syndrome in children with history of venous thromboembolism [J].
Creary, Susan ;
Heiny, Mark ;
Croop, James ;
Fallon, Robert ;
Vik, Terry ;
Hulbert, Monica ;
Knoderer, Holly ;
Kumar, Manjusha ;
Sharathkumar, Anjali .
BLOOD COAGULATION & FIBRINOLYSIS, 2012, 23 (01) :39-44
[4]   Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial [J].
Enden, Tone ;
Haig, Ylva ;
Klow, Nils-Einar ;
Slagsvold, Carl-Erik ;
Sandvik, Leiv ;
Ghanima, Waleed ;
Hafsahl, Geir ;
Holme, Pal Andre ;
Holmen, Lars Olaf ;
Njaastad, Anne Mette ;
Sandbaek, Gunnar ;
Sandset, Per Morten .
LANCET, 2012, 379 (9810) :31-38
[5]   Elevated plasma factor VIII and D-dimer levels as predictors of poor outcomes of thrombosis in children [J].
Goldenberg, NA ;
Knapp-Clevenger, R ;
Manco-Johnson, MJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (11) :1081-1088
[6]   A thrombolytic regimen for high-risk deep venous thrombosis may substantially reduce the risk of postthrombotic syndrome in children [J].
Goldenberg, Neil A. ;
Durham, Janette D. ;
Knapp-Clevenger, R. ;
Manco-Johnson, Marilyn J. .
BLOOD, 2007, 110 (01) :45-53
[7]   Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors [J].
Goldenberg, Neil A. ;
Donadini, Marco R. ;
Kahn, Susan R. ;
Crowther, Mark ;
Kenet, Gili ;
Nowak-Goettl, Ulrike ;
Manco-Johnson, Marilyn J. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (11) :1952-1959
[8]   Post-thrombotic syndrome is uncommon in childhood cancer survivors [J].
Journeycake, JM ;
Eshelman, D ;
Buchanan, GR .
JOURNAL OF PEDIATRICS, 2006, 148 (02) :275-277
[9]   Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome [J].
Kahn, S. R. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (05) :884-888
[10]   Definition of post-thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization [J].
Kahn, S. R. ;
Partsch, H. ;
Vedantham, S. ;
Prandoni, P. ;
Kearon, C. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (05) :879-883