Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles

被引：85

作者：

Karthikeyan, Mari Sithambaram ^{[1
]}

机构：

[1] Mangalore Univ, Dept Chem, Mangalagangothri 574199, Karnataka, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 02期

关键词：

3-(2,4-Dichloro-5-fluorophenyl)-4H-1,2,4-triazole-5-thiol; PPA cyclization; Thiazolotriazole; Biological activities; BIOLOGICAL-ACTIVITY; ANTIBACTERIAL; ANALOGS; METABOLISM; THIAZOLES; FLUORINE; SCHIFF;

D O I：

10.1016/j.ejmech.2008.04.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles (1) were synthesized starting from 3-(2,4-dichloro-5-fluorophenyl)-4H-1,2,4-triazole-3-thiol (5). The newly synthesized compounds were characterized by IR, H-1 NMR, mass and elemental analysis. Some of the synthesized compounds were tested for their anti-inflammatory, analgesic and antimicrobial activities. Compounds 8c, 8d and 8h exhibited excellent anti-inflammatory activity whereas compounds 8d, 8e and 8h showed excellent analgesic activity. Compounds 8a, 8c-e, and 8h exhibited good antibacterial activity and compounds 8c, 8e and 8h showed good antifungal activity. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：827 / 833

页数：7

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