Loss to follow-up of HIV-exposed infants for confirmatory HIV test under Early Infant Diagnosis program in India: analysis of national-level data from reference laboratories

被引：3

作者：

Gawde, Nilesh ^{[1
]}

Kamble, Suchit ^{[2
]}

Goel, Noopur ^{[2
]}

Nikhare, Kalyani ^{[2
]}

Bembalkar, Shilpa ^{[2
]}

Thorwat, Mohan ^{[2
]}

Jagtap, Dhanashree ^{[3
]}

Kurle, Swarali ^{[2
]}

Yadav, Neeru ^{[1
]}

Verma, Vinita ^{[4
]}

Kapoor, Neha ^{[4
]}

Das, Chinmoyee ^{[4
]}

机构：

[1] Tata Inst Social Sci, Mumbai, Maharashtra, India

[2] ICMR Natl AIDS Res Inst, Pune, Maharashtra, India

[3] ICMR Natl Inst Res Reprod Hlth, Mumbai, Maharashtra, India

[4] Natl AIDS Control Org, New Delhi, India

来源：

BMC PEDIATRICS | 2022年 / 22卷 / 01期

关键词：

Early infant diagnosis; HIV-exposed infants; Loss to follow-up from EID testing cascade; INDETERMINATE; INFECTION;

D O I：

10.1186/s12887-022-03656-w

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Early Infant Diagnosis was launched in India in 2010 and its effect on the diagnosis of HIV-exposed infants needs to be assessed. The present study was done to find out the median age at DBS sample collection for early infant diagnosis and its trend over years, the median age at diagnosis of HIV among the HIV-exposed infants with DNA PCR tests, and the proportion of infants who completed testing cascades after detection of HIV-1 in a sample. Methods DNA PCR data (from 2013 to 2017) maintained at all regional reference laboratories in India was collated with each infant identified by a unique code. Cohort analysis of the infant data was used to find the median age at sample collection and diagnosis. The outcomes of testing in each cascade and the overall outcomes of testing for infants were prepared. Results The median age at sample collection for the four years combined at all India level was 60 days (48-110 days). The median age at diagnosis of HIV was 285 days (174-418 days). HIV-1 was detected in samples of 1897 (6.3%) infants out of 30,216 infants who had a DNA PCR test, out of whom 1070 (56.4%) completed the testing cascade and the rest were lost to follow-up. Conclusion The data highlights delay in diagnosis; both due to delay in sample collection and turn-around-times. Loss to follow-up of HIV-exposed infants with virus detection is a significant concern to the Early Infant Diagnosis and tracking systems need to be strengthened.

引用

页数：7

共 14 条

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