Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease JACC Review Topic of the Week

被引：81

作者：

Cainzos-Achirica, Miguel ^{[1
,2
]}

Glassner, Kerri ^{[3
,4
,5
]}

Zawahir, Hassan Syed ^{[2
]}

Dey, Amit K. ^{[3
,4
]}

Agrawal, Tanushree ^{[1
]}

Quigley, Eamonn M. M. ^{[3
,4
]}

Abraham, Bincy P. ^{[3
,4
,5
]}

Acquah, Isaac ^{[2
]}

Yahya, Tamer ^{[2
]}

Mehta, Nehal N. ^{[6
]}

Nasir, Khurram ^{[1
,2
]}

机构：

[1] Houston Methodist DeBakey Heart & Vasc Ctr, Dept Cardiol, Div Cardiovasc Prevent & Wellness, 6550 Fannin St,Suite 1801, Houston, TX 77030 USA

[2] Houston Methodist, Ctr Outcomes Res, Houston, TX USA

[3] Houston Methodist Hosp, Lynda K & David M Underwood Ctr Digest Disorders, Houston, TX 77030 USA

[4] Weill Cornell Med Coll, Houston, TX USA

[5] Houston Methodist Hosp, Fondren IBD Program, Lynda K & David M Underwood Ctr Digest Disorders, Houston, TX 77030 USA

[6] NIH, Sect Inflammat & Cardiometab Dis, Bldg 10, Bethesda, MD 20892 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2020年 / 76卷 / 24期

关键词：

atherosclerosis; cardiovascular disease; inflammation; inflammatory bowel disease; prevention; MYOCARDIAL-INFARCTION; NATURAL-HISTORY; RISK-FACTORS; MORTALITY; METAANALYSIS; SMOKING; ABNORMALITIES; ASSOCIATION; MICROBIOME; PREVENTION;

D O I：

10.1016/j.jacc.2020.10.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic inflammatory diseases including human immunodeficiency virus infection, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus predispose to atherosclerotic cardiovascular disease (ASCVD). Inflammatory bowel disease (IBD) is a common chronic inflammatory condition, and the United States has the highest prevalence worldwide. IBD has so far been overlooked as a contributor to the burden of ASCVD among young and middle-age adults, but meta-analyses of cohort studies suggest that IBD is an independent risk factor for ASCVD. This review discusses the epidemiological links between IBD and ASCVD and potential mechanisms underlying these associations. ASCVD risk management of patients with IBD is challenging because of their young age and the inability of current risk scores to fully capture their increased risk. The role of IBD in current primary prevention guidelines is evaluated, and strategies for enhanced ASCVD risk reduction in patients with IBD are outlined. Finally, the authors discuss knowledge gaps and future research directions in this innovative field. (C) 2020 Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：2895 / 2905

页数：11

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