Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review

被引：11

作者：

Carvalho Soares, Flavia Fonseca ^{[1
]}

Poluha, Rodrigo Lorenzi ^{[2
]}

Canales, Giancarlo De la Torre ^{[2
]}

Costa, Yuri Martins ^{[3
]}

Nascimento, Gustavo G. ^{[4
]}

Rodrigues Conti, Paulo Cesar ^{[2
]}

Bonjardim, Leonardo Rigoldi ^{[1
]}

机构：

[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP, Brazil

[2] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont, Bauru, SP, Brazil

[3] Univ Estadual Campinas, Piracicaba Sch Dent, Dept Physiol Sci, Piracicaba, Brazil

[4] Aarhus Univ, Sect Periodontol, Dept Dent & Oral Hlth, Aarhus, Denmark

来源：

JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE | 2020年 / 34卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

chronic pain; genetic polymorphism; orofacial region; pain sensitivity; quantitative sensory testing; CATECHOL-O-METHYLTRANSFERASE; OPIOID RECEPTOR GENE; LOW-BACK-PAIN; SINGLE-NUCLEOTIDE POLYMORPHISM; TEMPOROMANDIBULAR-JOINT; FIBROMYALGIA SYNDROME; INDIVIDUAL-DIFFERENCES; PSYCHOLOGICAL-FACTORS; POSSIBLE ASSOCIATION; T102C POLYMORPHISM;

D O I：

10.11607/ofph.2641

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Aims: To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders. Methods: Electronic searches were conducted to identify observational studies and clinical trials investigating the association between genetic polymorphisms and orofacial pain sensitivity in healthy individuals and/or patients with chronic orofacial pain disorders. Searches were carried out in PubMed, Embase, and Scopus databases using Medical Subject Headings and free terms. Results: Seven studies fulfilled the eligibility criteria: four analyzed healthy subjects, two included chronic orofacial pain patients, and one included samples of healthy subjects and patients with neuropathic pain. The results showed that genes associated with mechanical and thermal pain sensitivity were mostly related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways. Conclusion: Genetic polymorphisms related to opioid, catecholaminergic, inflammatory, and dopaminergic pathways were associated with sensitivity to thermal and pressure stimuli in the orofacial region. Therefore, genetic factors should be taken into account for an accurate interpretation of orofacial pain sensitivity. These results will allow for a better understanding of the etiopathogenesis of chronic pain affecting the orofacial region, and consequently for finding new therapeutic targets.

引用

页码：353 / 363B

页数：13

共 129 条

[1]

ALIYAH S, 2018, NEUROLOGY S1, V91, pNI122, DOI DOI 10.1212/01.wnl.0000550673.85597.2d

[2] Somatosensory function following painful repetitive electrical stimulation of the human temporomandibular joint and skin [J].

Ayesh, E. E. ;

Jensen, T. S. ;

Svensson, P. .

EXPERIMENTAL BRAIN RESEARCH, 2007, 179 (03) :415-425

[3] Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients [J].

Barbosa, Flavia Regina ;

Matsuda, Josie Budag ;

Mazucato, Mendelson ;

Franca, Suzelei de Castro ;

Zingaretti, Sonia Marli ;

da Silva, Lucienir Maria ;

Martinez-Rossi, Nilce Maria ;

Faria Junior, Milton ;

Marins, Mozart ;

Fachin, Ana Lucia .

RHEUMATOLOGY INTERNATIONAL, 2012, 32 (02) :427-430

[4] Heritability of low back pain and the role of disc degeneration [J].

Battie, Michele C. ;

Videman, Tapio ;

Levalahti, Esko ;

Gill, Kevin ;

Kaprio, Jaakko .

PAIN, 2007, 131 (03) :272-280

[5] Pain modality- and sex-specific effects of COMT genetic functional variants [J].

Belfer, Inna ;

Segall, Samantha K. ;

Lariviere, William R. ;

Smith, Shad B. ;

Dai, Feng ;

Slade, Gary D. ;

Rashid, Naim U. ;

Mogil, Jeffrey S. ;

Campbell, Claudia M. ;

Edwards, Robert R. ;

Liu, Qian ;

Bair, Eric ;

Maixner, William ;

Diatchenko, Luda .

PAIN, 2013, 154 (08) :1368-1376

[6] Differential methylation of the TRPA1 promoter in pain sensitivity [J].

Bell, J. T. ;

Loomis, A. K. ;

Butcher, L. M. ;

Gao, F. ;

Zhang, B. ;

Hyde, C. L. ;

Sun, J. ;

Wu, H. ;

Ward, K. ;

Harris, J. ;

Scollen, S. ;

Davies, M. N. ;

Schalkwyk, L. C. ;

Mill, J. ;

Williams, F. M. K. ;

Li, N. ;

Deloukas, P. ;

Beck, S. ;

McMahon, S. B. ;

Wang, J. ;

John, S. L. ;

Spector, T. D. .

NATURE COMMUNICATIONS, 2014, 5

[7] A family-based investigation of cold pain tolerance [J].

Birklein, F. ;

Depmeier, C. ;

Rolke, R. ;

Hansen, C. ;

Rautenstrauss, B. ;

Prawitt, D. ;

Magerl, W. .

PAIN, 2008, 138 (01) :111-118

[8] Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity:: Possible implications for opiate addiction [J].

Bond, C ;

LaForge, KS ;

Tian, MT ;

Melia, D ;

Zhang, SW ;

Borg, L ;

Gong, JH ;

Schluger, J ;

Strong, JA ;

Leal, SM ;

Tischfield, JA ;

Kreek, MJ ;

Yu, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9608-9613

[9] The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia [J].

Bondy, B ;

Spaeth, M ;

Offenbaecher, M ;

Glatzeder, K ;

Stratz, T ;

Schwarz, M ;

de Jonge, S ;

Krüger, M ;

Engel, RR ;

Färber, L ;

Pongratz, DE ;

Ackenheil, M .

NEUROBIOLOGY OF DISEASE, 1999, 6 (05) :433-439

[10] A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging [J].

Borsook, David ;

Upadhyay, Jaymin ;

Chudler, Eric H. ;

Becerra, Lino .

MOLECULAR PAIN, 2010, 6

← 1 2 3 4 5 6 7 8 9 10 →