Tertiary lymphoid structures in human lung cancers, a new driver of antitumor immune responses

被引：32
作者：
Goc, Jeremy [1 ,2 ,3 ]
Fridman, Wolf-Herman [1 ,2 ,3 ]
Hammond, Scott A. [4 ]
Sautes-Fridman, Catherine [1 ,2 ,3 ]
Dieu-Nosjean, Marie-Caroline [1 ,2 ,3 ]
机构：
[1] Cordeliers Res Ctr, INSERM, Lab Canc & Immune Escape, U1138, Paris, France
[2] Univ Paris 06, UMRS1138, Paris, France
[3] Univ Paris 05, UMRS1138, Paris, France
[4] MedImmune, Oncol Res, Gaithersburg, MD USA
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 05期
关键词：
tumor immunology; tertiary lymphoid structure; tumor-infiltrating lymphocyte; dendritic cell; lung cancer; DENDRITIC CELLS; CONTEXTURE;
D O I：
10.4161/onci.28976
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
T-cell infiltrates are robust prognostic biomarkers in the majority of human cancers. However, the mechanisms that shape a protective T-cell response remain unclear. Our recent study implicates tertiary lymphoid structures in the shaping of an efficient and beneficial immune response in lung cancer patients.
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