Helping Chemists Discover New Antibiotics

被引：185

作者：

Blaskovich, Mark A. T. ^{[1
]}

Zuegg, Johannes ^{[1
]}

Elliott, Alysha G. ^{[1
]}

Cooper, Matthew A. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Community Open Antimicrobial Drug Discovery, Brisbane, Qld 4072, Australia

来源：

ACS INFECTIOUS DISEASES | 2015年 / 1卷 / 07期

关键词：

DRUG DISCOVERY;

D O I：

10.1021/acsinfecdis.5b00044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The world is facing a crisis in treating infectious diseases, with a scarcity of new antibiotics in development to treat the growing threat of drug-resistant "superbugs". We need new strategies to reinvigorate the antibiotic pipeline. In this Viewpoint we discuss one such approach, encouraging the community of synthetic chemists to participate in testing chemical diversity from their laboratories for antimicrobial potential. CO-ADD, the Community for Open Antimicrobial Drug Discovery, offers free screening against five bacteria and two fungi with follow up hit confirmation and validation, all with no strings attached.

引用

页码：285 / 287

页数：3

共 8 条

[1]

[Anonymous], 2013, Antibiotic resistance threats in the United States, 2013, P1

[2]

[Anonymous], 2015, National action plan for combating antibotic resistant bacteria

[3] Fix the antibiotics pipeline [J].

Cooper, Matthew A. ;

Shlaes, David .

NATURE, 2011, 472 (7341) :32-32

[4]

Davies S. C., CHIEF MED OFFICER AN, V2

[5] A new antibiotic kills pathogens without detectable resistance [J].

Ling, Losee L. ;

Schneider, Tanja ;

Peoples, Aaron J. ;

Spoering, Amy L. ;

Engels, Ina ;

Conlon, Brian P. ;

Mueller, Anna ;

Schaeberle, Till F. ;

Hughes, Dallas E. ;

Epstein, Slava ;

Jones, Michael ;

Lazarides, Linos ;

Steadman, Victoria A. ;

Cohen, Douglas R. ;

Felix, Cintia R. ;

Fetterman, K. Ashley ;

Millett, William P. ;

Nitti, Anthony G. ;

Zullo, Ashley M. ;

Chen, Chao ;

Lewis, Kim .

NATURE, 2015, 517 (7535) :455-+

[6] Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings [J].

Lipinski, CA ;

Lombardo, F ;

Dominy, BW ;

Feeney, PJ .

ADVANCED DRUG DELIVERY REVIEWS, 1997, 23 (1-3) :3-25

[7] Physicochemical properties of antibacterial compounds: Implications for drug discovery [J].

O'Shea, Rosemarie ;

Moser, Heinz E. .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (10) :2871-2878

[8] Drugs for bad bugs: confronting the challenges of antibacterial discovery [J].

Payne, David J. ;

Gwynn, Michael N. ;

Holmes, David J. ;

Pompliano, David L. .

NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (01) :29-40

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