Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

被引：120
作者：
Campoy, S
Jara, M
Busquets, N
de Rozas, AMP
Badiola, I
Barbé, J [1 ]
机构：
[1] Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Bellaterra, Barcelona, Spain
[2] Univ Autonoma Barcelona, IRTA, CReSA, E-08193 Bellaterra, Barcelona, Spain
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 08期
关键词：
D O I：
10.1128/IAI.70.8.4721-4725.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
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收藏
页码：4721 / 4725
页数：5
相关论文
共 23 条
  • [1] The ferric uptake regulation (Fur) repressor is a zinc metalloprotein
    Althaus, EW
    Outten, CE
    Olson, KE
    Cao, H
    O'Halloran, TV
    [J]. BIOCHEMISTRY, 1999, 38 (20) : 6559 - 6569
  • [2] Evidence for the transport of zinc(II) ions via the Pit inorganic phosphate transport system in Escherichia coli
    Beard, SJ
    Hashim, R
    Wu, GH
    Binet, MRB
    Hughes, MN
    Poole, RK
    [J]. FEMS MICROBIOLOGY LETTERS, 2000, 184 (02) : 231 - 235
  • [3] Virulence of antibiotic-resistant Salmonella typhimurium
    Björkman, J
    Hughes, D
    Andersson, DI
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) : 3949 - 3953
  • [4] Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection
    Camilli, A
    Mekalanos, JJ
    [J]. MOLECULAR MICROBIOLOGY, 1995, 18 (04) : 671 - 683
  • [5] Characterisation of a new operon encoding a Zur-like protein and an associated ABC zinc permease in Listeria monocytogenes
    Dalet, K
    Gouin, E
    Cenatiempo, Y
    Cossart, P
    Héchard, Y
    [J]. FEMS MICROBIOLOGY LETTERS, 1999, 174 (01) : 111 - 116
  • [6] DAVIES RW, 1980, ADV BACTERIAL GENETI
  • [7] Identification of a zinc-specific metalloregulatory protein, Zur, controlling zinc transport operons in Bacillus subtilis
    Gaballa, A
    Helmann, JD
    [J]. JOURNAL OF BACTERIOLOGY, 1998, 180 (22) : 5815 - 5821
  • [8] ROLE OF ACID TOLERANCE RESPONSE GENES IN SALMONELLA-TYPHIMURIUM VIRULENCE
    GARCIADELPORTILLO, F
    FOSTER, JW
    FINLAY, BB
    [J]. INFECTION AND IMMUNITY, 1993, 61 (10) : 4489 - 4492
  • [9] Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth
    Headley, V
    Hong, M
    Galko, M
    Payne, SM
    [J]. INFECTION AND IMMUNITY, 1997, 65 (02) : 818 - 821
  • [10] A flagellar gene fliZ regulates the expression of invasion genes and virulence phenotype in Salmonella enterica serovar Typhimurium
    Iyoda, S
    Kamidoi, T
    Hirose, K
    Kutsukake, K
    Watanabe, H
    [J]. MICROBIAL PATHOGENESIS, 2001, 30 (02) : 81 - 90
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