Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar Typhimurium virulence

被引：120
|
作者：
Campoy, S
Jara, M
Busquets, N
de Rozas, AMP
Badiola, I
Barbé, J [1 ]
机构：
[1] Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Bellaterra, Barcelona, Spain
[2] Univ Autonoma Barcelona, IRTA, CReSA, E-08193 Bellaterra, Barcelona, Spain
来源：
INFECTION AND IMMUNITY | 2002年 / 70卷 / 08期
关键词：
D O I：
10.1128/IAI.70.8.4721-4725.2002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
引用
收藏
页码：4721 / 4725
页数：5
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