Asymmetric Transfer Hydrogenation of 3-(Trifluoromethyl)quinolines

被引：14
|
作者：
Guo, Ran-Ning [1 ,2 ]
Chen, Zhang-Pei [2 ]
Cai, Xian-Feng [2 ]
Zhou, Yong-Gui [2 ]
机构：
[1] Dalian Univ Technol, Dept Chem, Dalian 116012, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2014年 / 46卷 / 20期
基金：
美国国家科学基金会;
关键词：
chiral phosphoric acid; transfer hydrogenation; quinolines; trifluoromethyl group; ENANTIOSELECTIVE TRANSFER HYDROGENATION; CATALYZED TRANSFER HYDROGENATION; CHIRAL PHOSPHORIC-ACIDS; ALPHA-IMINO ESTERS; ORGANOCATALYTIC TRANSFER HYDROGENATION; BRONSTED ACID; HANTZSCH ESTERS; HETEROAROMATIC-COMPOUNDS; REDUCTIVE AMINATION; PERFLUOROALKYLATION REACTIONS;
D O I：
10.1055/s-0033-1338661
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-(trifluoromethyl) quinolines was successfully developed with up to 98% ee. The new method provides a direct and facile access to chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethyl group.
引用
收藏
页码：2751 / 2756
页数：6
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