The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain

被引：12

作者：

Hu, Shan ^{[1
]}

Chen, Yu ^{[2
]}

Wang, Zhi-Fu ^{[3
]}

Mao-Ying, Qi-Liang ^{[1
]}

Mi, Wen-Li ^{[1
]}

Jiang, Jian-Wei ^{[1
]}

Wu, Gen-Cheng ^{[1
]}

Wang, Yan-Qing ^{[1
]}

机构：

[1] Fudan Univ, Dept Integrat Med & Neurobiol,Inst Brain Sci, State Key Lab Med Neurobiol,Inst Acupuncture Res, WHO Collaborating Ctr Tradit Med,Shanghai Med Col, Shanghai 200032, Peoples R China

[2] Guiyang Med Univ, Guiyang 550004, Guizhou, Peoples R China

[3] Fujian Univ Tradit Chinese Med, Dept Anat, Integrat Med Coll, Fuzhou 350122, Fujian, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2015年 / 2015卷

关键词：

SPINAL-CORD; RAT MODEL; IN-VITRO; MECHANICAL ALLODYNIA; SENSORY NEURONS; MURINE MODEL; ACTIVATION; PATHWAY; CONTRIBUTES; INFLAMMATION;

D O I：

10.1155/2015/973524

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Cancer-induced bone pain (CIBP) is a severe type of chronic pain. It is imperative to explore safe and effective analgesic drugs for CIBP treatment. Baicalein (BE), isolated from the traditional Chinese herbal medicine Scutellaria baicalensis Georgi (or Huang Qin), has been demonstrated to have anti-inflammatory and neuroprotective effects. In this study, we examined the effect of BE on CIBP and the mechanism of this effect. Intrathecal and oral administration of BE at different doses could alleviate the mechanical allodynia in CIBP rats. Intrathecal 100 mu g BE could inhibit the production of IL-6 and TNF-alpha in the spinal cord of CIBP rats. Moreover, intrathecal 100 mu g BE could effectively inhibit the activation of p-p38 and p-JNK MAPK signals in CIBP rats. The analgesic effect of BE may be associated with the inhibition of the expression of the inflammatory cytokines IL-6 and TNF-alpha and through the activation of p-p38 and p-JNK MAPK signals in the spinal cord. These findings suggest that BE is a promising novel analgesic agent for CIBP.

引用

页数：8

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