A new convenient transformation of erythromycin A into clarithromycin

被引：9

作者：

Allevi, P ^{[1
]}

Longo, A ^{[1
]}

Anastasia, M ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Chim & Biochem Med, I-20133 Milan, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 12期

关键词：

antibiotics; antibacterials; clarithromycin; erythromycin A; methylation;

D O I：

10.1016/S0968-0896(99)00230-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4 "-hydroxy groups, methylation of the resulting 2',4 "-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2749 / 2752

页数：4