HP1a: a structural chromosomal protein regulating transcription

被引：132

作者：

Eissenberg, Joel C. ^{[1
]}

Elgin, Sarah C. R. ^{[2
]}

机构：

[1] St Louis Univ, Sch Med, Doisy Res Ctr, Edward Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[2] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

TRENDS IN GENETICS | 2014年 / 30卷 / 03期

关键词：

HP1a; chromodomain; silencing; gene expression; HETEROCHROMATIN FORMATION; DROSOPHILA-MELANOGASTER; HISTONE MODIFICATIONS; DISTINCT COMPLEXES; RNA INTERFERENCE; MECHANISM; GENOME; PHOSPHORYLATION; DOMAIN; PIWI;

D O I：

10.1016/j.tig.2014.01.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Heterochromatin protein 1 (HP1a in Drosophila) is a conserved eukaryotic chromosomal protein that is prominently associated with pericentric heterochromatin and mediates the concomitant gene silencing. Mechanistic studies implicate HP1 family proteins as 'hub proteins,' able to interact with a variety of chromosomal proteins through the chromo-shadow domain (CSD), as well as to recognize key histone modification sites [primarily histone H3 di/trimethyl Lys9 (H3K9me2/3)1 through the chromodomain (CD). Consequently, HP1 has many important roles in chromatin architecture and impacts both gene expression and gene silencing, utilizing a variety of mechanisms. Clearly, HP1 function is altered by context, and potentially by post-translational modifications (PTMs). Here, we report on recent ideas as to how this versatile protein accomplishes its diverse functions.

引用

页码：103 / 110

页数：8

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