Efficacy and safety of tranexamic acid in geriatric hip fracture with hemiarthroplasty: a retrospective cohort study

BackgroundGeriatric hip fracture patients are particularly susceptible to blood loss and venous thromboembolism (VTE) during hemiarthroplasty, yet relatively few studies have examined the safety and efficacy of tranexamic acid (TXA) in these patients.MethodsThis cohort study of hip fracture patients (65years) undergoing hemiarthroplasty between January 2013 and September 2016 involved 289 patients who received 15mg/kg TXA prior to surgery and 320 who received no TXA. All patients underwent a fast-track program including nutrition, blood, and pain management; VTE prophylaxis; early mobilization; and early intake. The primary outcome was red cell transfusion requirement. Secondary outcomes included blood loss, hemoglobin (Hb) level, VTE, adverse events and length of hospital stay. Multivariate logistic regression and meta-analysis of the literature were also performed to control for confounding factors and identify risk factors of red cell transfusion.ResultsThe proportion of patients receiving at least 1U of erythrocytes was significantly lower in the TXA group (8.65%) than in the control group (24.06%, OR 0.299, p<0.001). Mean Hb level was significantly higher in the TXA group on postoperative day 1 (111.70 18.40 vs 107.29 +/- 18.70g/L, p=0.008) and postoperative day 3 (108.16 +/- 17.25 vs 104.22 +/- 15.16g/L, p=0.005). A significantly higher proportion of TXA patients began to ambulate within 24h after surgery (37.02% vs 26.25%, p=0.004), and their length of hospitalization was significantly shorter (11.82 +/- 4.39 vs 15.96 +/- 7.30days, p=0.003). TXA did not increase risk of DVT (OR 0.70, 95%CI 0.25 to 1.97). Logistic regression showed that, after adjusting for covariates, TXA was associated with 62% lower risk of red blood cell transfusion (0.327, 95%CI 0.214 to 0.696), and a similar result was obtained in meta-analysis of unadjusted data from the present study and the literature (OR 0.33, 95%CI 0.25 to 0.43).Conclusion TXA appears to be safe and effective for reducing blood loss and red blood cell transfusion in geriatric hip fracture patients undergoing fast-track hemiarthroplasty.