Genetic analysis of noroviruses associated with fatalities in healthcare facilities

被引：57

作者：

Okada, M.

Tanaka, T.

Oseto, M.

Takeda, N.

Shinozaki, K.

机构：

[1] Chiba Prefectural Inst Publ Hlth, Div Virol, Chuo Ku, Chiba 2608715, Japan

[2] Sakai City Inst Publ Hlth, Sakai, Osaka, Japan

[3] Ehime Prefecture Inst Publ Hlth & Environm Sci, Div Microbiol, Matsuyama, Ehime, Japan

[4] Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan

来源：

ARCHIVES OF VIROLOGY | 2006年 / 151卷 / 08期

关键词：

D O I：

10.1007/s00705-006-0739-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Norovirus outbreaks occurred in 236 healthcare facilities for the elderly in Japan during the winter of 2004-2005. Three norovirus strains associated with three fatal clinical courses were isolated from geographically separate facilities and genetically analyzed along with three strains from non-fatal cases in the same season. All six isolates were classified as the GII-4 genotype. No new variant strains like those observed in Europe in 2002 and 2004 were found in fatal cases, and the three outbreaks were deemed to have been caused by genetically close conventional norovirus GII-4 strains.

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页码：1635 / 1641

页数：7

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