One pot synthesis of doxorubicin loaded gold nanoparticles for sustained drug release

被引：30

作者：

Chaudhary, Abhishek ^{[1
]}

Dwivedi, Charu ^{[1
]}

Gupta, Abhishek ^{[1
]}

Nandi, Chayan K. ^{[1
]}

机构：

[1] Indian Inst Technol Mandi, Sch Basic Sci, Mandi 175001, Himachal Prades, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 118期

关键词：

SILICA NANOPARTICLES; CANCER; OXIDATION; DELIVERY; ANTICANCER; MONOLAYER; COMPLEXES;

D O I：

10.1039/c5ra12892g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we report a facile, versatile and simple one-pot synthesis of doxorubicin (Dox) loaded gold nanoparticles (Dox-GNP conjugate), where Dox can act both as a reducing as well as a capping agent. Interestingly, when the conjugate was placed into the transporter protein environment, it avoided the undesirable multilayer protein corona formation, which is very common for nanomaterials. The in vitro drug release kinetic studies and the cytotoxicity assay and cellular update efficiency advocates that the system is capable of sustained release of the drug even in the presence of a complex biological environment.

引用

页码：97330 / 97334

页数：5

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