Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

被引：109

作者：

Burli, Roland W.

Xu, Han

Zou, Xiaoming

Muller, Kristine

Golden, Jennifer

Frohn, Mike

Adlam, Matthew

Plant, Matthew H.

Wong, Min

McElvain, Michele

Regal, Kelly

Viswanadhan, Vellarkad N.

Tagari, Philip

Hungate, Randall

机构：

[1] Amgen Inc, Chem Res & Discovery, Thousand Oaks, CA 91320 USA

[2] Amgen Inc, Inflammat, Thousand Oaks, CA 91320 USA

[3] Amgen Inc, Pharmakokinet & Drug Metab, Thousand Oaks, CA 91320 USA

[4] Amgen Inc, Mol Struct, Thousand Oaks, CA 91320 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 14期

关键词：

inflammation; G-protein-coupled receptor; hFPRL1; ALXR; pyrazolones;

D O I：

10.1016/j.bmcl.2006.04.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 mu M concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3713 / 3718

页数：6

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